Ester Solvent Mixture Prevents Tebuconazole Crystallization
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Solution Overview
Problem
Current solvent systems for phytosanitary formulations face challenges in achieving good solvent power and miscibility with water, while also ensuring safety, low toxicity, and stability, particularly for difficult-to-formulate active ingredients like tebuconazole, which can crystallize and cause issues during dilution and storage.
Innovation Solution
A composition comprising a mixture of compounds A of formula (I) and amide or ester solvents, specifically designed to provide excellent solvent power and miscibility with water, preventing crystallization and offering a favorable toxicological and ecological profile, including a blend of compounds such as Rhodiasolv Polarclean and ADMA 810.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If N-methylpyrrolidone (NMP) is used as a co-solvent to improve solubilization and prevent crystal formation, then the solvent power and stability are improved, but the toxicity and reprotoxicity increase, posing hazards to operators and users
Solution Approach 1:
The patent changes the chemical composition parameters by replacing NMP with a specific mixture of esters (ethyl 2-methylbutanoate, ethyl 2-methylpropanoate, ethyl butanoate, ethyl propanoate, ethyl hexanoate, ethyl octanoate, ethyl decanoate) that have different molecular structures and lower toxicity profiles while maintaining the solubilization function
Solution Approach 2:
The patent uses a composite solvent system comprising multiple ester compounds in specific proportions (each ester at 5-30% by weight) rather than a single solvent, creating a synergistic mixture that achieves both high solubilization capacity and reduced toxicity compared to NMP
2Productivity
If plant protection products are formulated at relatively high concentrations to improve transport efficiency and packaging, then the productivity is improved, but the risk of crystal formation increases during dilution and storage, causing clogging and distribution problems
Solution Approach 1:
The patent changes the solvent composition parameters to include specific esters with optimal chain lengths and branching that provide enhanced solubilization power, enabling formulation at high concentrations (up to 250 g/L or more) while preventing crystal formation through the specific molecular interactions of the ester mixture
Solution Approach 2:
The ester mixture acts as an intermediary substance between the active ingredient and water, facilitating high-concentration formulation and stable dilution by preventing the active ingredient from crystallizing during the transition from concentrated formulation to diluted application solution
3Quantity of substance
If solvents with high solvent power are used to solubilize difficult-to-formulate active ingredients like tebuconazole, then the solubilization capacity is improved, but the miscibility with water deteriorates, making dilution difficult
Solution Approach 1:
The patent employs a composite ester system combining different chain-length esters (propanoate through decanoate) that collectively provide both high solubilization capacity for hydrophobic active ingredients and adequate water miscibility through the shorter-chain components, achieving a balance that single solvents cannot provide
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively solubilizes significant quantities of active ingredients, prevents crystallization under demanding conditions, and provides a stable and safe formulation for agricultural use, ensuring effective distribution and minimizing environmental impact.
Implementation Method 1
The composition effectively solubilizes significant quantities of active ingredients, prevents crystallization under demanding conditions
Data Source
Figure 1~2
AI summary
The present invention relates to a composition including: 10 to 90 wt % of a mixture M of compounds A having formula R1CONR2R3, where R1 is, in particular, a linear or branched saturated aliphatic group having 1-6 carbon atoms, and R2 and R3, which are identical or different, are, in particular, methyl or ethyl groups; and 10 to 90 wt % of at least one compound B selected from the amide solvents, optionally combined with an ester solvent.