Ethanol Sclerosing Agent Stability and Tracing
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Solution Overview
Problem
Current ethanol-based sclerosing agents for treating vascular malformations have unsatisfactory drug effects and lack accurate tracing capabilities, posing risks due to ethanol's erosive nature and instability when mixed with iodized oil.
Innovation Solution
An ethanol-based sclerosing agent comprising ethanol, a water-soluble iodine preparation, and water, with ethanol volume percentage ranging from 76% to 98% and a specific mass-volume ratio of iodine, enhancing stability and tracing capabilities.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If ethanol is used as a sclerosing agent, then therapeutic efficacy is improved, but safety deteriorates due to erosive nature and inability to trace
Solution Approach 1:
The patent introduces a water-soluble iodine preparation as an intermediary substance mixed with ethanol. This intermediary serves dual purposes: it provides radiographic contrast for tracing ethanol distribution and dilutes ethanol to reduce its erosive harmful effects on normal tissues while maintaining therapeutic efficacy on vascular malformations
Solution Approach 2:
The patent changes the concentration parameter of ethanol from pure or high concentration to a diluted formulation containing 76%-98% ethanol (rather than 100%). This parameter change reduces the harmful erosive effects while maintaining the sclerosing therapeutic effect, and allows for safe clinical use
2Measurement precision
If iodized oil is mixed with ethanol for tracing, then tracing capability is improved, but stability deteriorates due to separation and embolism risk
Solution Approach 1:
The patent changes the physical state and solubility parameters of the iodine-containing substance. Instead of using iodized oil (insoluble in water), the patent employs a water-soluble iodine preparation, which fundamentally changes the mixture's stability by ensuring complete solubility in the aqueous-ethanol solution, preventing separation and embolism
Solution Approach 2:
The patent creates a stable composite solution by combining ethanol, water, and water-soluble iodine preparation in specific proportions. This composite material maintains homogeneous mixing without separation, unlike the ethanol-iodized oil mixture, while providing both therapeutic and tracing functions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The proposed sclerosing agent achieves accurate tracing of ethanol, improves therapeutic efficacy for vascular malformations, and reduces the risk of irreversible damage to normal tissues, with enhanced stability and embolization efficiency.
Implementation Method 1
a water-soluble iodine preparation... can be tracked after intravascular injection
Implementation Method 2
denatures hemoglobin through dehydration and denudation and destroys vascular endothelial cells, rapidly causing focal tissue necrosis and thrombosis
Data Source
AI summary
Disclosed are an ethanol hardener and the use thereof. The ethanol hardener contains ethanol, a water-soluble iodine preparation and water, wherein the volume percent of the ethanol is 76-98%, and the mass-volume ratio of the iodine element in the water-soluble iodine preparation to the iodine containing composition is 23-139 g/L. The iodine containing composition can be autoradiographed when injected into blood vessels, and has a better embolization effect and stability.