High-Purity Ethanol Injection for Tissue Ablation
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Solution Overview
Problem
Current medicinal alcohol products have impurities and low purity, which can lead to toxic exposure and instability, failing to effectively ablate tissues or perform therapeutic neurolysis with the desired precision and safety.
Innovation Solution
A pharmaceutical-grade ethanol product with at least 99% purity, synthesized from petrochemical-derived ethylene, is developed for injection, ensuring high stability and minimal toxic impurities, and is used in methods like tissue ablation and therapeutic neurolysis through precise delivery via catheters and syringes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If fermented ethanol is used to produce medicinal alcohol, then the production cost is reduced, but the purity is lowered and toxic impurities are introduced
Solution Approach 1:
The patent extracts and eliminates harmful impurities from ethanol through a multi-step purification process including activated carbon filtration, distillation, and molecular sieve technology. This removes toxic substances while maintaining the therapeutic benefits of ethanol for tissue ablation and neurolysis procedures.
Solution Approach 2:
The patent changes the purity parameter of ethanol from typical medicinal grades (95-98%) to ultra-high purity (99.9% or higher) through advanced purification techniques. This parameter change eliminates toxic impurities while preserving ethanol's therapeutic efficacy for medical applications.
2Device complexity
If less pure ethanol is used, then the manufacturing process is simpler, but toxic impurities are introduced and stability is reduced
Solution Approach 1:
The patent implements preliminary purification actions during the manufacturing process, including pre-filtration through activated carbon, intermediate distillation steps, and final polishing with molecular sieves. These preliminary actions prevent impurity accumulation and ensure product stability before storage and clinical use.
3Reliability
If high-purity synthetic ethanol is used, then toxic impurities are minimized and stability is improved, but the production cost increases
Solution Approach 1:
The patent uses intermediary substances and processes such as activated carbon, distillation media, and molecular sieves as mediators to achieve ultra-high purity ethanol. These intermediaries facilitate the removal of impurities while allowing the ethanol to maintain its therapeutic properties for tissue ablation and neurolysis.
4Manufacturing precision
If impure medicinal alcohol is used for tissue ablation, then the treatment may be less effective, but the risk of toxic exposure increases
Solution Approach 1:
The patent employs strong oxidation processes during purification, such as controlled oxidation steps that selectively remove organic impurities and contaminants while preserving the ethanol molecule. This accelerated oxidation ensures toxic substances are eliminated, making the ethanol safe for tissue ablation and neurolysis procedures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The high-purity ethanol product effectively ablates tissues and nerves with minimal impact on healthy tissue, providing improved therapeutic outcomes and extended shelf-life, enhancing patient care for various diseases, including rare conditions and veterinary applications.
Implementation Method 1
improved methods for ablating tissues and performing therapeutic neurolysis
Implementation Method 2
The high-purity ethanol product effectively ablates tissues and nerves with minimal impact on healthy tissue
Data Source
AI summary
A liquid injectable pharmaceutical drug product consisting of no less that 99 percent ethanol comprised of no less than 99 percent ethanol active pharmaceutical ingredient with a volume of at least 0.05 mL to be injected into a patient as a method of ablating/lysing cells.