Ethoxysilane Therapeutic Agent for Solid Cancer Hardening
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Solution Overview
Problem
The increasing number of small lung cancer lesions, particularly in elderly patients, poses challenges for complete removal through surgery and radiation therapy, as these methods are invasive and limited by the number of lesions and total therapeutic dose.
Innovation Solution
A liquid therapeutic agent containing an ethoxy-containing compound, such as ethoxysilane, which infiltrates and hardens within cancer cells through polycondensation, inducing death or growth inhibition via ethanol release and heat from exothermic reactions, allowing for site-specific treatment without tissue ablation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If surgical treatment or radiation therapy is used for small lung cancer lesions, then local treatment effect is achieved, but the treatment is invasive and limited by the number of lesions and total therapeutic dose
Solution Approach 1:
The invention changes the physical state parameter of the therapeutic agent from solid to liquid, enabling injection through fine needles. The liquid composition infiltrates cancer cells and undergoes polycondensation hardening in vivo, transforming from a liquid injectable form to a solidified treatment agent within the target tissue, thereby achieving effective local treatment with minimal invasiveness
Solution Approach 2:
The invention replaces mechanical surgical removal and physical radiation therapy with a chemical-based treatment mechanism. The liquid composition uses chemical polycondensation reactions to harden within cancer cells, and the released ethanol and exothermic heat induce cancer cell death, substituting mechanical and physical treatment methods with a chemical reaction-based approach
2Reliability
If complete removal of multiple lesions is attempted through surgery, then curative treatment is achieved, but the procedure becomes excessively invasive and unsafe for elderly patients
Solution Approach 1:
The invention changes the physical state parameter of the therapeutic agent from solid to liquid, enabling injection through fine needles. The liquid composition infiltrates cancer cells and undergoes polycondensation hardening in vivo, transforming from a liquid injectable form to a solidified treatment agent within the target tissue, thereby achieving effective local treatment with minimal invasiveness
Solution Approach 2:
The invention applies treatment locally at the cancer lesion site through injection, with the liquid composition infiltrating only the target cancer cells. The polycondensation hardening and ethanol release occur locally within the injected tissue, providing site-specific treatment that spares surrounding healthy tissue and eliminates the need for extensive surgical intervention
3Reliability
If radiation therapy dose is increased to treat multiple cancers simultaneously, then treatment effectiveness improves, but the upper limit of total therapeutic radiation dose is exceeded
Solution Approach 1:
The invention changes the physical state parameter of the therapeutic agent from solid to liquid, enabling injection through fine needles. The liquid composition infiltrates cancer cells and undergoes polycondensation hardening in vivo, transforming from a liquid injectable form to a solidified treatment agent within the target tissue, thereby achieving effective local treatment with minimal invasiveness
Solution Approach 2:
The invention divides the treatment approach into multiple independent injectable units, each targeting a specific cancer lesion. The liquid composition can be injected into multiple separate lesions independently, with each injection site undergoing local polycondensation hardening, thereby enabling treatment of multiple cancers without exceeding a single radiation dose limit
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The agent provides a less invasive, site-specific treatment for solid cancers, effectively inhibiting cancer cell growth and death, suitable for multiple lesions and elderly patients, with reduced risk of metastasis and improved diagnostic accuracy.
Implementation Method 1
a liquid composition containing an ethoxy-containing compound capable of undergoing polycondensation in a cellular tissue
Implementation Method 2
be hardened by a reaction in which water in the body is involved
Implementation Method 3
death or growth inhibition of the solid cancer cells can be induced by the resulting hardened matter, as well as ethanol released during the hardening reaction and heat generated by exothermic reaction
Data Source
AI summary
A novel therapeutic agent for solid cancer capable of hardening the cellular tissue itself of a solid cancer to induce death or growth inhibition of cancer cells, causing solidification of the tissue, is disclosed. The therapeutic agent for solid cancer is composed of a liquid composition containing as an active component an ethoxy-containing compound capable of undergoing polycondensation in a cellular tissue. The therapeutic agent for solid cancer is capable of hardening the cellular tissue itself of a solid cancer such as lung cancer to induce death or growth inhibition of cancer cells, causing solidification of the tissue. In conventional therapeutic methods, the risk of metastasis due to spreading of cancer cells through the bloodstream cannot be eliminated. In contrast, this therapeutic agent for solid cancer instantly surrounds cancer cells, so that the risk of metastasis can be largely reduced.