Ethylene Oxide-Treated Dressing Sustained Release

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Solution Overview

Problem

Existing wound dressings containing polysulfated oligosaccharides have insufficient sustained bioavailability of active ingredients, leading to frequent dressing changes and suboptimal treatment efficacy, particularly in wound healing and stretch mark prevention/treatment, due to rapid depletion of active ingredients.

Innovation Solution

Development of dressings with a micro-adherent interface containing polysulfated oligosaccharides, such as the potassium salt of sucrose octasulfate, treated with ethylene oxide, which provides a sustained release of active ingredients, maintaining effective bioavailability for extended periods.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If dressings contain polysulfated oligosaccharides for wound healing, then treatment efficacy is improved, but active ingredient bioavailability depletes rapidly requiring frequent dressing changes

Engineering Contradiction:

Improvetreatment efficacyVSAvoidbioavailability duration

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent applies parameter changes by treating the dressing with ethylene oxide, which modifies the physical and chemical properties of the dressing material. This treatment alters the matrix structure to control the release kinetics of polysulfated oligosaccharides, transforming rapid depletion into sustained release over extended periods while maintaining therapeutic efficacy.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The ethylene oxide treatment enables continuous and sustained release of active ingredients from the dressing. By modifying the matrix structure, the treatment ensures that polysulfated oligosaccharides are released continuously over time rather than depleting rapidly, maintaining constant bioavailability at the wound site and eliminating the need for frequent dressing changes.

Inventive Principle:

Principle #20Continuity of useful action

2Reliability

If dressings are changed frequently to maintain active ingredient levels, then treatment efficacy is maintained, but time loss and operational complexity increase

Engineering Contradiction:

Improvetreatment efficacyVSAvoidtime for dressing changes

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The ethylene oxide-treated dressing provides continuous release of active ingredients throughout the wound healing process. This sustained bioavailability eliminates the need for frequent dressing changes, thereby reducing time loss and operational complexity while maintaining treatment efficacy throughout the entire healing period.

Inventive Principle:

Principle #20Continuity of useful action

3Duration of action of moving object

If ethylene oxide treatment is applied to dressings, then sustained release of active ingredients is achieved, but manufacturing process complexity increases

Engineering Contradiction:

Improverelease durationVSAvoidmanufacturing process complexity

Core Design Contradiction:

Duration of action of moving objectVSDevice complexity

Solution Approach 1:

The ethylene oxide treatment is applied as a preliminary step during the dressing manufacturing process, before the dressing is packaged and distributed. This preliminary action modifies the matrix structure in advance, enabling sustained release of active ingredients without requiring complex additional components or post-processing steps during actual use.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The manufacturing process incorporates ethylene oxide treatment to permanently alter the physical and chemical parameters of the dressing matrix. This parameter change is integrated into the manufacturing workflow, creating a modified matrix structure that inherently provides sustained release functionality without adding significant process complexity.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The ethylene oxide-treated dressings exhibit a higher and sustained release of active ingredients, enhancing treatment efficacy by maintaining effective bioavailability for longer durations, reducing the need for frequent dressing changes and improving wound healing and stretch mark prevention/treatment outcomes.

Implementation Method 1

the dressing having been subjected to treatment with ethylene oxide... exhibit a higher and sustained release of active ingredients

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 2

characterized by a dissolution higher or equal to 4% in 5 h, higher or equal to 5% in 10 h, higher or equal to 5.5% in 15 h, higher or equal to 6% in 20 h

Methodology Applied

Scientific EffectDissolution:

Data Source

PatentUS10172972B2Dressing having sustained release of active agents

Publication Date: 2019.01.08 LABORATOIRES URGO SAS

AI summary

The present disclosure relates to novel dressings containing polysulfated oligosaccharides having sustained release of the active ingredients. It also relates to a method for the preparation thereof, this method including a treatment step with ethylene oxide. It further relates to the uses thereof for wound care and the treatment and/or prevention of scars and stretch marks.