Eubacterium Nodatum Composition for Sarcopenia and Osteoporosis
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Solution Overview
Problem
There are no effective drugs available for treating muscle diseases such as sarcopenia and bone diseases like osteoporosis, and existing treatments for other conditions are not adequately addressing these issues.
Innovation Solution
A composition comprising Eubacterium nodatum or its culture is used as an active ingredient to formulate food, quasi-drug, or pharmaceutical compositions to prevent or treat bone and muscle diseases, and improve athletic performance by increasing bone density, muscle strength, and grip strength.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional drugs are used for treating muscle and bone diseases, then existing treatments can address other conditions, but they are not adequately effective for sarcopenia and osteoporosis
Solution Approach 1:
The patent uses Eubacterium nodatum as a mediator between the gut microbiome and bone-muscle health. The bacterium produces butyrate and other metabolites that act as intermediaries to improve bone density and muscle strength, resolving the contradiction by providing a targeted mechanism that works specifically for bone and muscle diseases while maintaining the ability to be formulated for other conditions.
Solution Approach 2:
The invention changes the therapeutic parameter from conventional drugs to probiotic bacteria (Eubacterium nodatum) and its metabolites. This parameter change enables specific effectiveness for bone and muscle diseases through mechanisms like butyrate production, IGF-1 activation, and Wnt pathway modulation, which are not adequately addressed by existing drugs.
2Strength
If Eubacterium nodatum is used to increase bone density and muscle strength, then athletic performance improves, but the complexity of formulation and administration increases
Solution Approach 1:
The patent formulates Eubacterium nodatum to serve multiple functions simultaneously: improving bone density, increasing muscle strength, enhancing athletic performance, and preventing sarcopenia and osteoporosis. This multi-functionality reduces the need for separate treatments for each condition, thereby simplifying the overall therapeutic approach despite the complex biological mechanisms involved.
Solution Approach 2:
The probiotic Eubacterium nodatum colonizes the gut and continuously produces beneficial metabolites like butyrate, creating a self-sustaining therapeutic effect. This self-service mechanism reduces the need for frequent administrations and complex monitoring, simplifying the treatment regimen while maintaining improved muscle strength and bone density.
Data Source
AI summary
The present invention relates to a composition for preventing or treating bone and muscle disease comprising Eubacterium nodatum or a culture thereof. The present composition comprising Eubacterium nodatum or a culture thereof have the effect of increasing bone density, bone area, bone volume and bone thickness, increasing grip strength and muscle weight, and improving athletic performance.