Existing Aliquot Sample Tubes for Late Add-On Testing

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Solution Overview

Problem

Current laboratory middleware systems lack flexibility in handling additional tests on aliquot sample tubes, often requiring new aliquots to be created from primary tubes, leading to inefficiencies and increased costs.

Innovation Solution

A method and system that utilizes existing aliquot sample tubes for additional tests by determining their availability and location, transporting them to analytical devices if necessary, and reassigned to primary tubes if timeouts occur, ensuring efficient use of resources.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a new aliquot is created from the primary tube for additional tests, then the additional test can be performed, but laboratory time and resources are wasted and costs increase

Engineering Contradiction:
Improvetest accuracyVSAvoidlaboratory processing time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The system performs preliminary actions by creating aliquots in advance before additional tests are requested. When an initial test is ordered, the system proactively creates aliquots and stores them in the automation system, so that when additional tests are requested later, ready-to-use aliquots are already available rather than needing to create new ones from the primary tube.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system dynamically adjusts its behavior based on real-time conditions. The workflow engine continuously monitors for additional test requests and automatically determines whether to use existing aliquots or create new ones based on current system state, aliquot availability, and test requirements, making flexible decisions rather than following rigid predefined paths.

Inventive Principle:
Principle #15Dynamics

2Reliability

If a new aliquot is created from the primary tube for additional tests, then the additional test can be performed, but costs and resource consumption increase

Engineering Contradiction:
Improvetest accuracyVSAvoidsample consumption
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The system performs preliminary actions by creating aliquots in advance before additional tests are requested. When an initial test is ordered, the system proactively creates aliquots and stores them in the automation system, so that when additional tests are requested later, ready-to-use aliquots are already available rather than needing to create new ones from the primary tube.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system recovers and reuses existing biological material by creating multiple aliquots from a single primary sample tube. These aliquots can be used for multiple different tests over time, effectively recovering the sample material for repeated use rather than repeatedly consuming from the primary tube.

Inventive Principle:
Principle #34Discarding and recovering

3Adaptability or versatility

If the workflow engine creates a new aliquot for additional tests, then test requests are fulfilled, but laboratory efficiency and performance decrease

Engineering Contradiction:
Improvetest flexibilityVSAvoidlaboratory throughput
Core Design Contradiction:
Adaptability or versatilityVSProductivity

Solution Approach 1:

The system performs preliminary actions by creating aliquots in advance before additional tests are requested. When an initial test is ordered, the system proactively creates aliquots and stores them in the automation system, so that when additional tests are requested later, ready-to-use aliquots are already available rather than needing to create new ones from the primary tube.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system provides self-service by automatically detecting additional test requests and autonomously retrieving appropriate aliquots or creating new ones without requiring manual intervention. The workflow engine monitors for new tests, queries the database for existing aliquots, and automatically routes samples through the automation system, making the entire process self-managing.

Inventive Principle:
Principle #25Self-service

4Device complexity

If the system does not check for existing aliquots before creating new ones, then the workflow is simple, but economic and performance issues arise

Engineering Contradiction:
Improveworkflow complexityVSAvoidlaboratory efficiency
Core Design Contradiction:
Device complexityVSProductivity

Solution Approach 1:

The system implements feedback by continuously monitoring for additional test requests and automatically querying the database to check for existing aliquots before proceeding. The workflow engine receives feedback about test requests, checks aliquot availability status, and adjusts its actions based on this information, creating a closed-loop system that prevents unnecessary aliquot creation.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system provides self-service by automatically detecting additional test requests and autonomously retrieving appropriate aliquots or creating new ones without requiring manual intervention. The workflow engine monitors for new tests, queries the database for existing aliquots, and automatically routes samples through the automation system, making the entire process self-managing.

Inventive Principle:
Principle #25Self-service

Data Source

PatentUS12449432B2Add-on and repetition aliquot testing with or without dilutions
Publication Date: 2025.10.21 ROCHE DIAGNOSTICS OPERATIONS INC
  • US12449432B2 patent drawing
  • US12449432B2 patent drawing
  • US12449432B2 patent drawing

AI summary

A method of assigning an additional test to an existing aliquot sample tube or to a primary sample tube in a laboratory automation system is presented. The laboratory automation system comprises a workflow control unit and analytical laboratory devices in communication with the workflow control unit. The method comprises receiving an additional test request for the existing aliquot sample tube after processing of the existing aliquot sample tube has started, determining if the existing aliquot sample tube is at a retrievable target, waiting until the existing aliquot sample tube reaches a retrievable target if not at a retrievable target, determining if an aliquot timeout has occurred once the existing aliquot sample tube is at a retrievable target, reassigning the addition test to the primary sample tube if an aliquot timeout has occurred, and performing the additional test from the existing aliquot sample tube if no aliquot timeout has occurred.