Expandable Intravascular Device for Coronary Reperfusion
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Solution Overview
Problem
Current reperfusion therapies after percutaneous coronary intervention (PCI) often result in reperfusion injury, characterized by inflammatory responses and oxidative damage, which can hinder the restoration of normal tissue function and blood flow.
Innovation Solution
A system comprising an intravascular reperfusion therapy device with an expandable structure and sensors to monitor and control blood flow, using physiological data to adjust the expansion of the device to optimize back pressure and delivery of reperfusion therapy, thereby minimizing injury and enhancing tissue perfusion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If reperfusion therapy is delivered to restore blood flow to ischemic tissue, then tissue perfusion is improved, but reperfusion injury occurs causing inflammatory response and oxidative damage
Solution Approach 1:
The expandable structure transitions from a compressed low-profile configuration during delivery to an expanded configuration at the target site, dynamically adapting its form to achieve therapeutic effect while minimizing injury. The structure can be selectively expanded or collapsed to control blood flow modulation.
Solution Approach 2:
The system changes physical parameters of the expandable structure including its radial dimension, axial dimension, and degree of expansion to control the degree of venous obstruction and back pressure generation, thereby optimizing reperfusion therapy delivery while minimizing tissue damage.
2Productivity
If an expandable structure is used to generate back pressure in a coronary vein, then reperfusion therapy delivery is improved, but device complexity increases
Solution Approach 1:
The expandable structure comprises multiple segments or sections that can be independently controlled or that expand in a coordinated manner. This segmentation allows for localized control of back pressure and simplified deployment mechanisms compared to a monolithic structure.
Solution Approach 2:
The expandable structure is configured to be nested within itself or within the delivery catheter in a compressed state during delivery, then expanded at the target site. This nesting principle reduces delivery profile complexity while enabling complex therapeutic function at the destination.
3Measurement precision
If physiological sensors are integrated to monitor blood flow, then therapy control precision is improved, but device complexity increases
Solution Approach 1:
The expandable structure serves multiple functions: it provides mechanical obstruction to generate back pressure, delivers therapeutic agents, and integrates physiological sensors for monitoring. This multi-functionality reduces the need for separate dedicated components, thereby managing overall device complexity while achieving precise monitoring and control.
4Productivity
If the expandable structure is fully expanded to maximize back pressure, then reperfusion therapy effectiveness is improved, but risk of vessel obstruction increases
Solution Approach 1:
The expandable structure enables dynamic adjustment of its expansion state, transitioning between partially expanded and fully expanded configurations. This allows real-time optimization of back pressure generation while monitoring physiological parameters to prevent excessive obstruction, thereby balancing therapy effectiveness with safety.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively adapts the reperfusion therapy to improve blood flow and reduce tissue damage, ensuring more efficient and effective restoration of blood flow to ischemic areas, thereby minimizing reperfusion injury and promoting healthier tissue function.
Implementation Method 1
the plurality of arms, when expanded, may generate a back pressure within a coronary vein to deliver reperfusion therapy to a myocardium
Implementation Method 2
the intravascular reperfusion therapy device may include a sensor (e.g., a sensing component), which may sense physiological data (e.g., flow data, pressure data, and/or the like) representative of blood flow through the blood vessel
Data Source
AI summary
A system includes an intravascular reperfusion therapy device positionable within a coronary vein to deliver reperfusion therapy to a myocardium of a heart. The intravascular reperfusion therapy device includes a catheter and a sensor. The catheter includes a plurality of arms configured to expand into the coronary vein to deliver the reperfusion therapy by obstructing blood flow in a first direction to generate back pressure in an opposite, second direction. The system includes a processor circuit that receives, from the sensor, physiological data associated with blood flow, determines, based on the physiological data, a progression of the reperfusion therapy, and controls, based on the progression of the reperfusion therapy, expansion of the plurality of arms while the intravascular reperfusion therapy device is positioned within the coronary vein such that the back pressure within the coronary vein is controlled.