Expanded Collagenous Matrix for Implant Persistence
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
There is a challenge in obtaining extracellular matrix materials with the necessary physical and biological properties for medical applications, such as joint repair and wound healing, as existing materials often lack persistence and vascular ingrowth when implanted.
Innovation Solution
The development of a bioactive composite extracellular matrix material comprising a denatured, expanded extracellular matrix treated with an alkaline medium, which retains bioactive components like growth factors, and is processed into various forms for enhanced implant persistence and tissue generation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional extracellular matrix materials are used, then the materials are biocompatible and can be derived from various biological sources, but they lack persistence and fail to encourage vascular ingrowth when implanted
Solution Approach 1:
The patent applies parameter changes by treating extracellular matrix material with alkaline solutions to denature collagen and alter physical properties. This chemical treatment modifies the matrix structure to create a more persistent implant that maintains integrity while encouraging vascular ingrowth, resolving the contradiction between persistence and productivity
Solution Approach 2:
The patent creates composite materials by combining treated extracellular matrix with additional components to enhance both persistence and vascular ingrowth capabilities. The composite structure integrates multiple functional properties that address both contradictory requirements simultaneously
2Reliability
If extracellular matrix material is expanded through alkaline treatment, then persistence and vascular ingrowth are improved, but the structural integrity and original matrix architecture may be compromised
Solution Approach 1:
The patent carefully controls the parameters of alkaline treatment (concentration, time, temperature) to achieve denaturation that improves persistence without completely destroying the matrix architecture. By optimizing these parameters, the treatment enhances vascular ingrowth while maintaining sufficient structural integrity
Solution Approach 2:
The patent maintains continuous structural support through the treatment process by preserving the overall matrix framework while modifying specific regions. The expanded material continues to provide a scaffold for tissue regeneration, ensuring uninterrupted useful action throughout the implant lifecycle
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The expanded extracellular matrix materials exhibit improved persistence and encourage vascular ingrowth, promoting effective tissue regeneration and healing in medical applications.
Implementation Method 1
an extracellular matrix material that has been treated with an alkaline medium under conditions effective to produce an expanded extracellular matrix material
Data Source
AI summary
Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non-expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.