Extended-Duration Local Anesthetic Formulation for Lower Toxicity
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Solution Overview
Problem
Current local and regional anesthetics provide limited duration of analgesia, often leading to toxicity issues and complications, and there is a need for extended duration anesthesia with minimal toxicity for surgical procedures and chronic pain management.
Innovation Solution
A kit comprising a short duration local anesthetic in solution and a powdered long duration anesthetic, such as tetracaine, is provided in separate chambers, allowing for mixing at the time of use to create a dilute solution that can be injected for extended analgesia, reducing toxicity risks and enabling safer, longer-lasting anesthesia.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If high concentration local anesthetics are used to extend duration of analgesia, then duration of action is improved, but toxicity increases
Solution Approach 1:
The anesthetic agent is divided into two separate components: a short-acting local anesthetic in liquid form and a long-acting local anesthetic in powdered form. These components are stored separately in a multi-chamber device and mixed only at the time of administration, allowing the combination to provide extended duration of analgesia while maintaining lower concentrations of each individual agent to reduce toxicity
Solution Approach 2:
The kit allows for preliminary preparation by storing pre-measured amounts of short-acting and long-acting anesthetics in separate chambers. At the time of use, these components are mixed in a predetermined ratio to create the extended-duration formulation, ensuring proper dosing while minimizing toxicity risks before administration to the patient
2Reliability
If high concentration local anesthetics are used to ensure adequate anesthesia, then reliability of analgesia is improved, but harmful effects increase
Solution Approach 1:
The invention combines two different local anesthetic agents with distinct duration characteristics into a single composite formulation. The short-acting component provides immediate and reliable onset of analgesia, while the long-acting component extends the duration, creating a composite product that ensures reliable pain control without requiring high concentrations of a single agent that would increase harmful effects
3Duration of action of moving object
If extended duration anesthesia is provided using current formulations, then duration of action is improved, but motor blockade increases
Solution Approach 1:
The invention changes the concentration parameters of the anesthetic agents by using lower concentrations of each component (short-acting and long-acting) compared to traditional high-concentration formulations. This parameter change allows the extended-duration formulation to provide adequate analgesia while minimizing motor blockade, as the lower individual concentrations reduce the cumulative motor-blocking effect
Data Source
AI summary
An extended duration anesthetic includes a short duration local anesthetic in a dilute solution and a long duration local anesthetic. The long duration local anesthetic is maintained in a powdered form until the time of administration. Premeasured quantities of the dilute solution and powdered long duration local anesthetic in a kit allow for quick preparation of a solution with desired concentrations of both short duration local anesthetic and long duration local anesthetic at the time of administration.