Extended-Release Liquid Nitric Oxide Solutions for Wound Treatment
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Solution Overview
Problem
Existing treatments for delivering nitric oxide (NO) to treat wounds and infections are inefficient, require multiple applications, and are limited to the site of administration, failing to address distal sites or situations where time is constrained.
Innovation Solution
A liquid nitric oxide releasing solution (NORS) that combines a nitric oxide releasing compound and an acidifying agent, allowing for quick delivery and extended release of gaseous NO at the treatment site, even when the administration site is distant, using lower concentrations of nitrites and acids to minimize toxicity and maximize efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If direct exposure to nitric oxide gas is used to treat wound infections, then effective antimicrobial action is achieved, but the patient must be connected to a gas cylinder for 8 hours at a time which is not suitable when time is constrained
Solution Approach 1:
The patent transforms nitric oxide from a gaseous form requiring prolonged exposure into a liquid solution form that can be administered quickly. The liquid nitric oxide releasing solution changes the physical state parameter, allowing rapid delivery while maintaining therapeutic efficacy through extended release mechanism.
Solution Approach 2:
The patent introduces a liquid solution as an intermediary carrier that delivers nitric oxide indirectly. Instead of direct gas exposure, the liquid solution serves as a mediator that releases nitric oxide at the treatment site, enabling quick administration without requiring continuous gas cylinder connection.
2Quantity of substance
If inorganic nitrite and organic acid are used to produce NO on skin surface, then NO delivery is achieved, but the system is messy, impractical, causes pain in open wounds and possibly causes further damage
Solution Approach 1:
The patent converts the potentially harmful reactive intermediates into a stable liquid solution that releases nitric oxide gently. Instead of using raw inorganic nitrite and organic acid combinations that cause pain and damage, the invention transforms them into a pre-mixed liquid formulation that delivers the same therapeutic benefit without the harmful side effects.
Solution Approach 2:
The patent changes the concentration parameters and physical state of the nitric oxide precursors. By formulating them as a liquid solution with controlled concentrations, the system achieves effective NO delivery while reducing the harmful effects associated with higher concentrations and inappropriate physical forms.
3Ease of operation
If solid, liquid, cream or other non-gaseous NO donors are used, then easier administration is achieved, but toxic side effects occur due to acidic environment required for release and binding of nitric oxide with other compounds
Solution Approach 1:
The patent uses a liquid solution as an intermediary that reduces direct toxic interactions. The liquid formulation acts as a gentle carrier that releases nitric oxide without the severe acidic environment and compound binding issues associated with solid and cream formulations, thereby reducing toxic side effects while maintaining ease of administration.
4Quantity of substance
If existing NO delivery methods are used, then treatment at administration site is achieved, but distal sites are not treated and multiple applications are required
Solution Approach 1:
The patent implements extended release of nitric oxide from the liquid solution over time. This continuous release mechanism ensures that nitric oxide is delivered not only at the administration site but also reaches distal sites through systemic circulation, eliminating the need for multiple reapplications and expanding treatment coverage.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Provides a therapeutically effective, prolonged release of NO for up to 24 hours, effectively treating wounds and infections at both the administration site and distal sites without the need for continuous connection to a gas source, suitable for ambulatory patients.
Implementation Method 1
A liquid nitric oxide releasing solution (NORS) that combines a nitric oxide releasing compound and an acidifying agent, allowing for quick delivery and extended release of gaseous NO
Data Source
AI summary
The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment, prevention, or reduction of incidence of a disease or disorder in a human in need thereof, the method comprising administering to the human a liquid NORS comprised of at least one nitrite compound at a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO.