Extended Release Particle Dispersion via Liquid Preproduct Mixing
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Solution Overview
Problem
Current extended release preparations, such as biodegradable microparticles, face issues like the use of toxic organic solvents, complex production processes, low encapsulation efficiency, stability problems during storage, and the need for aseptic preparation, which complicate administration and patient compliance.
Innovation Solution
A ready-to-use liquid composition of extended release particles is formed by mixing two liquid preproducts, where one preproduct contains a carrier material that solidifies to form the particles, and the other preproduct is a biocompatible liquid, allowing for immediate administration without separate drying or reconstitution steps.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If biodegradable microparticles are prepared by solvent evaporation method, then extended release of active compound is achieved, but toxic organic solvents are used and complex production processes are required
Solution Approach 1:
The patent changes the physical state parameter of the carrier material from solid to liquid, enabling the active compound to be dissolved or dispersed in a liquid carrier that can be directly injected. This eliminates the need for organic solvents and complex drying processes while maintaining extended release functionality through the liquid-to-solid transition in the body.
Solution Approach 2:
The patent extracts and eliminates toxic organic solvents from the formulation by using a liquid carrier material that is free from harmful substances. The carrier material itself serves as the vehicle for the active compound without requiring additional solvent systems.
2Stability of the object's composition
If microparticles are stored separately from aqueous suspension vehicle, then hydrolytic stability is maintained, but reconstitution step is required and administration is complicated
Solution Approach 1:
The patent merges the carrier material and aqueous suspension vehicle into a single ready-to-use liquid composition. The liquid carrier material is formulated to be compatible with aqueous environments, allowing direct injection without separation or reconstitution steps while maintaining stability through appropriate formulation.
Solution Approach 2:
The patent performs preliminary formulation work by pre-mixing the active compound with the liquid carrier material in a stable, ready-to-use composition. This preliminary preparation eliminates the need for reconstitution at the time of administration, simplifying the process while maintaining stability through proper formulation design.
3Stability of the object's composition
If dry powder microparticles are used, then storage stability is improved, but separate storage and reconstitution are required
Solution Approach 1:
The patent changes the physical state of the composition from dry powder to liquid formulation. The liquid carrier material maintains stability during storage and transitions to a solid or semi-solid state in the body, providing extended release without requiring dry powder handling or reconstitution equipment.
4Manufacturing precision
If complex production processes are used, then microparticle formation is achieved, but manufacturing complexity and cost increase
Solution Approach 1:
The patent extracts and eliminates complex production steps such as solvent evaporation, drying, and reconstitution from the manufacturing process. The liquid carrier material formulation allows direct injection without requiring complex processing equipment or multiple production stages.
Solution Approach 2:
The patent simplifies manufacturing by changing the formulation from requiring phase transitions and drying steps to a direct liquid injection system. The liquid carrier material can be directly administered without complex processing, reducing manufacturing complexity while maintaining therapeutic efficacy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach simplifies the preparation and administration of extended release particles, reducing production complexity and improving patient compliance by providing a ready-to-use, stable, and efficient delivery method for active compounds.
Implementation Method 1
the first liquid preproduct comprises a carrier material that solidifies to form the extended release particles
Implementation Method 2
a ready-to-use liquid composition of extended release particles is formed by mixing two liquid preproducts
Data Source
AI summary
The invention relates to extended release compositions that can be advantageously used as drug products, plant protection agents, in foods or other products. The invention especially relates to liquid compositions in which extended release particles are dispersed. The compositions according to this invention are available in the form of single-dose or multi-dose compositions and as such are produced from liquid preproducts. The invention further relates to kits and methods for producing the compositions and to the preproducts thereof.