External Vagus Nerve Stimulation via Magnetic Induction

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Solution Overview

Problem

Current treatments for nausea and vomiting, such as medications and implanted vagus nerve stimulation devices, are not universally effective and often come with risks or undesirable implanted power sources, particularly for pregnant women or patients requiring temporary relief.

Innovation Solution

An external current source is used to apply electrical signals to the vagus nerve through electrodes placed on or under the skin, eliminating the need for an implanted power supply and allowing for non-invasive treatment of nausea and vomiting by magnetic induction or direct electrical stimulation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If an implanted vagus nerve stimulation device is used, then the treatment effectiveness for nausea and vomiting is improved, but the device complexity and surgical invasiveness increase

Engineering Contradiction:
Improvetreatment effectivenessVSAvoiddevice complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent extracts the power source and control electronics from the implanted device, placing them externally. This removes the need for implanted batteries and complex circuitry while maintaining vagus nerve stimulation capability, thereby reducing device complexity and surgical invasiveness while preserving treatment effectiveness

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The system is divided into separate components: an external power and control unit, and a simpler implanted electrode array. This segmentation allows the complex functions to be housed externally while the implanted portion remains minimal, reducing overall device complexity and surgical requirements

Inventive Principle:
Principle #1Segmentation

2Duration of action of stationary object

If an implanted power supply is used, then continuous stimulation is possible, but the surgical invasiveness and patient discomfort increase

Engineering Contradiction:
Improvecontinuous stimulation capabilityVSAvoidsurgical invasiveness
Core Design Contradiction:
Duration of action of stationary objectVSEase of manufacture

Solution Approach 1:

The power supply is extracted from the implanted device and placed in an external unit. This eliminates the need for surgical implantation of batteries or power sources, reducing surgical invasiveness and patient discomfort while allowing continuous stimulation through the external power unit

Inventive Principle:
Principle #2Taking out (Extraction)

3Ease of operation

If medications are used for treating nausea and vomiting, then the treatment is non-invasive, but the effectiveness is not universal and fetal risks exist

Engineering Contradiction:
Improvenon-invasive treatmentVSAvoidtreatment effectiveness
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The patent uses electrical stimulation as an intermediary mechanism between the external power source and the vagus nerve. This provides a non-invasive treatment approach (external power source) while achieving reliable effectiveness through direct neural stimulation, avoiding both medication risks and implanted power sources

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach effectively reduces nausea and vomiting without the risks associated with implanted devices, providing a convenient and safe treatment option for patients, including pregnant women, by using an external power source for vagus nerve stimulation.

Implementation Method 1

applying electrical current from an external current source to a vagus nerve of a patient

Methodology Applied
Scientific EffectElectrical stimulation: Conduction (electrical)

Implementation Method 2

allowing for non-invasive treatment of nausea and vomiting by magnetic induction or direct electrical stimulation

Methodology Applied
Scientific EffectMagnetic induction: Electromagnetic Induction

Data Source

PatentUS10322284B2Method for treating nausea and vomiting by vagus nerve stimulation with selectable stimulation modes
Publication Date: 2019.06.18 JOHNS HOPKINS UNIVERSITY
  • US10322284B2 patent drawing
  • US10322284B2 patent drawing
  • US10322284B2 patent drawing

AI summary

A system and method for treating nausea and vomiting are provided, including one or more electrodes (10, 12) applied on or under the skin, the electrodes being connected to an external current source (34). The electrodes can be implanted under the skin and connect to internal stimulator electronics (22), which can form a magnetic inductive link to the external current source (34). Alternatively, the electrodes can be placed on the skin and directly linked by wires to the external current source. As a further alternative, the vagus nerve can be directly stimulated in the neck, or the esophagus, stomach, duodenum, or intestines can be directly stimulated by magnetic stimulation. The electrodes can stimulate the vagus nerve in the neck to reduce nausea and vomiting, or can be arranged near the chest or abdomen, so as to stimulate the esophagus, stomach, duodenum or intestines. Because the current source is provided outside the body, it is not necessary to implant batteries or another power supply in the body.