Antigen-Deprived Extracellular Matrix Composite for Anastomotic Reinforcement
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Solution Overview
Problem
Existing surgical reinforcing devices face challenges in providing sufficient strength to fragile tissues during anastomotic procedures while minimizing immunogenicity and ensuring biocompatibility, as conventional materials do not adequately support tissue healing or prevent staple-induced damage.
Innovation Solution
An anastomotic/occlusion reinforcing and repairing composite member comprising a reinforcing and repairing portion with a three-dimensional mesh-like structure made from antigen-deprived extracellular matrix material, a protection portion for safeguarding the connecting thread, and a detachable braided mesh-like structure for secure attachment, which is designed for use with surgical staplers to enhance tissue strength and facilitate easy assembly.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If conventional synthetic reinforcing materials (polypropylene, polylactic acid) are used, then the tissue gains mechanical strength to prevent tearing, but the materials cannot help wound healing and show permanent foreign body presence
Solution Approach 1:
The patent changes the material parameters from conventional synthetic materials to antigen-deprived extracellular matrix materials, transforming the chemical composition and biological properties to achieve both mechanical strength and biocompatibility
Solution Approach 2:
The patent uses composite material structure combining antigen-deprived extracellular matrix with specific mechanical properties, integrating the benefits of biological compatibility and structural support
2Productivity
If bare anastomotic staples are used directly on tissue, then the surgical procedure is simple and fast, but fragile tissue cannot be protected from being torn by staples
Solution Approach 1:
The reinforcing material is pre-applied to the tissue surface before stapling, creating a protective layer that prevents staple-induced tissue damage while maintaining surgical efficiency
3Reliability
If reinforcing materials are applied to protect fragile tissue, then tissue tearing is prevented, but the materials do not promote wound healing
Solution Approach 1:
The patent modifies the material parameters by using antigen-deprived extracellular matrix that contains growth factors and biochemical signals, transforming the material from purely mechanical support to active wound healing promoter
Data Source
AI summary
The present disclosure relates to the technical field of medical equipment and discloses an anastomotic/occlusion reinforcing and repairing composite member which includes a reinforcing and repairing portion, a protection portion and a connecting thread, wherein two ends of the reinforcing and repairing portion are detachably connected by the connecting thread; and the protection portion penetrates into a space enclosed by the two ends of the reinforcing and repairing portion. The present disclosure also provides a preparation and application method of the anastomotic/occlusion reinforcing and repairing composite member.