Extracellular matrix systems, devices, and methods of deployment

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Solution Overview

Problem

Existing nerve injury treatments, including FDA-approved products, primarily focus on passive support and do not show clinical improvement in functional outcomes, leading to prolonged recovery times and poor prognoses for patients with peripheral nerve injuries.

Innovation Solution

A system comprising an extracellular matrix derived from tissue, a neutralizing element, and a reconstituting element, configured to interact and modify properties to promote nerve regeneration and structural support, including deployment methods such as intra-mesoneurium and peri-mesoneurium deployment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If passive support products are used for nerve injury treatment, then mechanical stability is improved, but functional recovery is not enhanced

Engineering Contradiction:

Improvemechanical stabilityVSAvoidfunctional recovery

Core Design Contradiction:

StrengthVSReliability

Solution Approach 1:

The patent employs a composite material system consisting of an extracellular matrix scaffold combined with growth factors and neutralizing elements. This composite approach integrates structural support (scaffold) with biological activity (growth factors), enabling both mechanical stability and functional recovery enhancement simultaneously

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent modifies the chemical and biological parameters of the nerve injury site by introducing specific growth factors (NGF, BDNF, GDNF, IGF-1) and neutralizing elements (enzymes, antibodies, peptides) that change the local microenvironment, thereby promoting axonal regeneration and functional recovery beyond passive mechanical support

Inventive Principle:

Principle #35Parameter changes

2Strength

If existing FDA-approved nerve products are used, then mechanical support is provided, but recovery time is prolonged

Engineering Contradiction:

Improvemechanical supportVSAvoidrecovery time

Core Design Contradiction:

StrengthVSLoss of time

Solution Approach 1:

The patent incorporates neutralizing elements that are pre-positioned within or with the extracellular matrix scaffold before implantation. These elements (enzymes, antibodies, peptides) immediately begin neutralizing harmful factors and promoting regeneration upon deployment, eliminating the delay associated with post-implantation activation

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent establishes continuous biological activity through the sustained release of growth factors and neutralizing elements from the extracellular matrix scaffold over time. This continuous action maintains a pro-regenerative environment throughout the recovery period, accelerating the regeneration process compared to passive support that provides no ongoing biological stimulation

Inventive Principle:

Principle #20Continuity of useful action

3Productivity

If extracellular matrix with neutralizing and reconstituting elements is used, then nerve regeneration is accelerated, but device complexity increases

Engineering Contradiction:

Improvenerve regeneration rateVSAvoidsystem complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The patent merges multiple functional components (extracellular matrix scaffold, growth factors, neutralizing elements) into a single integrated implant system. This consolidation delivers multiple therapeutic mechanisms simultaneously through one device, achieving accelerated regeneration without requiring multiple separate treatments or complex surgical procedures

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system accelerates nerve regeneration and improves functional recovery by providing structural and biological support, potentially reducing recovery time and enhancing therapeutic benefits.

Implementation Method 1

a neutralizing element; wherein the neutralizing element and/or reconstituting element are configured to interact with the extracellular matrix, and the interaction causes a change to the extracellular matrix

Methodology Applied

Scientific EffectNeutralization:

Implementation Method 2

a reconstituting element; wherein the neutralizing element and/or reconstituting element are configured to interact with the extracellular matrix, and the interaction causes a change to the extracellular matrix

Methodology Applied

Scientific EffectReconstitution:

Data Source

PatentUS12364790B2Extracellular matrix systems, devices, and methods of deployment

Publication Date: 2025.07.22 RENERVA LLC

AI summary

Systems, devices, and methods for treating a nerve injury in a patient are provided. The system includes an extracellular matrix, a neutralizing element, and a reconstituting element. The extracellular matrix is configured to promote and/or sustain the growth of tissue and/or associated tissue properties proximate the nerve injury.