Endoluminal Extroducer Device for Microvasculature Access
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current medical devices are inadequate for delivering substances to and/or from conventionally difficult-to-access target sites, such as the microvasculature, and fail to prevent bleeding at penetration sites, especially in arterial vessels, due to their large size and inability to navigate small vessels safely.
Innovation Solution
An endoluminal medical access device, known as the extroducer, which features a hollow body with a detachable distal portion that can penetrate and communicate with extravascular spaces through a microvasculature, allowing for targeted delivery or sampling without leaving a catheter in place, and automatically seals at physiological pressures to prevent bleeding.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a vessel wall penetrating catheter is used to deliver substances to extravascular target sites, then access to difficult-to-reach organs is improved, but the device size becomes too large to navigate microvasculature
Solution Approach 1:
The catheter is divided into a proximal portion and a distal penetrator portion that can separate from each other. The distal penetrator portion is left in place at the target site after delivery, while the proximal portion is withdrawn through the vasculature. This segmentation allows the device to navigate microvasculature in its assembled state while leaving only the essential functional element at the target site.
Solution Approach 2:
The proximal portion of the catheter is extracted and withdrawn from the body after substance delivery is complete. Only the distal penetrator portion remains at the target site, eliminating the need to maintain a large catheter connection all the way through the vasculature and reducing the risk of thrombotic embolies.
2Reliability
If a catheter is left in place at the penetration site to prevent bleeding, then hemostasis is improved, but the risk of thrombotic embolies and device-related complications increases
Solution Approach 1:
The proximal portion of the catheter is extracted and withdrawn from the body after substance delivery is complete. Only the distal penetrator portion remains at the target site, eliminating the need to maintain a large catheter connection all the way through the vasculature and reducing the risk of thrombotic embolies.
Solution Approach 2:
The distal penetrator portion is designed as a temporary, disposable element that remains only long enough to deliver the substance and seal the penetration site. It is not intended for long-term implantation, reducing the risk of chronic thrombotic complications while providing sufficient hemostasis during the critical delivery period.
3Reliability
If adhesive or embolizing material is injected to prevent bleeding during catheter retraction, then hemostasis is improved, but the procedure complexity and risk of unintentional vessel occlusion increase
Solution Approach 1:
The distal penetrator portion is designed to seal the penetration site automatically through its own structure and the natural physiological processes at the target site. The device itself provides the hemostatic function through its design, eliminating the need for additional adhesive materials or complex embolization procedures.
4Quantity of substance
If a large catheter is used to deliver substances to target sites, then delivery capability is improved, but navigation into microvasculature becomes impossible
Solution Approach 1:
The catheter is divided into a proximal portion and a distal penetrator portion that can separate from each other. The distal penetrator portion is left in place at the target site after delivery, while the proximal portion is withdrawn through the vasculature. This segmentation allows the device to navigate microvasculature in its assembled state while leaving only the essential functional element at the target site.
Solution Approach 2:
The distal penetrator portion is nested within the proximal portion of the catheter during navigation through the vasculature. This nested configuration minimizes the overall device diameter, allowing navigation into microvasculature while protecting the distal penetrator until it reaches the target site.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The extroducer device enables minimally invasive, safe delivery and sampling in small vessels, including the CNS and pancreas, with reduced risk of bleeding and thrombotic embolies, and can be used on both arterial and venous sides, providing a high engraftment ratio for transplanted cells and efficient substance administration.
Implementation Method 1
automatically seals at physiological pressures to prevent bleeding
Data Source
Figure 1~2
Figure 3A~3B
Figure 4a~4b
AI summary
An endoluminal medical access device (1) is disclosed that is devised for endoluminal delivery to an extravascular target site (5) at a vasculature site of a human or animal body vasculature, such as the microvasculature. The device (1 ) comprises a hollow body (112) arranged around a continuous channel (113) that ends in a distal end (100) and comprises a distal penetration portion (102) that is devised to extend across a tissue wall of said microvasculature said microvasculature site (4) at an extravascular target site in said body to provide communication with said extravascular target site through said channel (113) and devised for at least partly apposition to said tissue wall, and a proximal connection section (101 ), which proximally adjoins said penetration portion (102), and optionally comprises an intrusion depth limit unit (116, 118) and/or a hollow separation section (115) devised to provide a controllable separation of the penetration portion (102) from a connected proximal portion (110) of the hollow body.