Extruded Non-Replicating Probiotics for Storage Stability
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for rendering probiotics non-replicating, such as heat-treatment, γ-irradiation, and chemical agents, are not scalable for industrial use and often result in a loss of health benefits, limiting their application in food products and posing challenges in maintaining viability during storage and consumption.
Innovation Solution
The use of extrusion technology to render probiotic microorganisms non-replicating by subjecting them to high temperatures and mechanical shearing, creating a bioactive extruded matrix that retains substantial health benefits, allowing for broader product applications and industrial scalability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If heat-treatment is used to render probiotics non-replicating, then the probiotics become stable for storage, but they lose their health benefits
Solution Approach 1:
The invention changes the physical parameters of probiotics through extrusion processing, transforming them from a replicating state to a non-replicating state while preserving bioactive components. This parameter transformation allows the probiotics to maintain storage stability without suffering the health benefit loss associated with conventional heat-treatment
2Reliability
If γ-irradiation or UV-treatment is used to render probiotics non-replicating, then the probiotics become non-replicating, but the methods are not scalable for industrial use
Solution Approach 1:
The invention replaces complex radiation systems (γ-irradiation, UV-treatment) with a mechanical extrusion system. This substitution maintains the ability to produce non-replicating probiotics while achieving industrial scalability through continuous processing and simpler equipment requirements
3Reliability
If chemical agents are used to render probiotics non-replicating, then the probiotics become non-replicating, but the methods are problematic for industrial application
Solution Approach 1:
The invention extracts and eliminates the need for chemical agents from the probiotic inactivation process. By using purely mechanical extrusion, the method removes harmful chemical substances while achieving the desired non-replicating state, thereby improving ease of manufacture and industrial applicability
4Object-affected harmful factors
If probiotics are kept viable during storage, then they maintain health benefits, but it is not a trivial task and requires special conditions
Solution Approach 1:
Instead of trying to maintain probiotics in a viable state during storage (which requires complex conditions), the invention inverts the approach by rendering probiotics non-replicating before storage. This inversion eliminates the need for special storage conditions while preserving health benefits through the extrusion process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The extrusion process effectively generates non-replicating probiotics that maintain immune-stimulating activities, offering improved or new health benefits comparable to their viable counterparts, suitable for a wide range of products and addressing concerns of viability and storage issues.
Implementation Method 1
subjecting them to high temperatures and mechanical shearing
Implementation Method 2
subjecting them to high temperatures and mechanical shearing
Data Source
AI summary
The present invention generally relates to the field of pro biotic micro-organisms, in particular to the field of non-replicating probiotic micro-organisms. Embodiments of the present invention relate to compositions comprising probiotic microorganisms that were rendered non-replicating by extrusion. Such compositions may be used to treat or prevent disorders that are related to a compromised immune system.