Bovine FABP4 SNP Analysis for Beef Cattle Breeding Efficiency

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current animal breeding techniques for improving beef production are costly and inefficient, requiring years of genetic evaluation and facing regulatory resistance, with a need for more efficient selection and breeding methods that utilize genetic markers for economically relevant traits like leptin levels, growth rate, and carcass quality.

Innovation Solution

Identification of single nucleotide polymorphisms (SNPs) in the bovine FABP4 gene and their association with economically relevant traits, enabling the sub-grouping of animals based on genotype and predicting desirable phenotypes, along with computer-assisted methods for managing livestock data and improving production efficiency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If classical animal breeding techniques are used to improve beef production, then animal performance and carcass quality can be improved, but the process requires several years of genetic evaluation and is very expensive

Engineering Contradiction:
Improveanimal performance improvementVSAvoidevaluation time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent applies preliminary action by identifying and selecting animals based on genetic markers (SNPs) in the FABP4 gene before traditional phenotypic evaluation is completed. By determining genotype status in advance using molecular biology techniques, the system can predict meat quality traits and make breeding decisions earlier in the production cycle, reducing the several years of evaluation time required by classical methods.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent replaces the mechanical/phenotypic evaluation system with a molecular genetic system. Instead of relying on physical measurement and observation of animal traits over time, the invention uses DNA sequencing and SNP analysis to directly assess genetic potential for meat quality, thereby accelerating the selection process and reducing evaluation time.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Productivity

If feed additives, animal hormonal implants and chemotherapeutics are used to improve productivity, then production efficiency can be improved, but there is significant political and regulatory resistance

Engineering Contradiction:
Improveproduction efficiencyVSAvoidregulatory resistance
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent applies self-service by utilizing the animal's own genetic information to guide breeding and production decisions. By analyzing the animal's FABP4 genotype, the system enables natural selection and breeding strategies that improve productivity without requiring external interventions such as feed additives or hormonal implants, thereby avoiding regulatory resistance associated with these substances.

Inventive Principle:
Principle #25Self-service

3Productivity

If marker-assisted selection using genetic markers is applied, then selection and breeding efficiency can be improved, but the complexity of data management and analysis increases

Engineering Contradiction:
Improvebreeding efficiencyVSAvoiddata management complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The patent applies the extraction principle by isolating and focusing analysis on a specific, highly relevant gene region (FABP4) with known associations with meat quality traits. Rather than managing complex data across the entire genome, the system extracts and analyzes only the critical SNP markers in the FABP4 gene, simplifying data management while maintaining high breeding efficiency through targeted genetic evaluation.

Inventive Principle:
Principle #2Taking out (Extraction)

Data Source

PatentUS7919241B2Polymorphisms in fatty acid binding protein 4 (“FABP4”) gene and their associations with measures of marbling and subcutaneous fat depth in beef cattle
Publication Date: 2011.04.05 WASHINGTON STATE UNIVERSITY
  • US7919241B2 patent drawing
  • US7919241B2 patent drawing
  • US7919241B2 patent drawing

AI summary

The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of single nucleotide polymorphisms (SNPs) within the bovine genes encoding fatty acid binding proteins and their associations with economically relevant traits in beef production. The invention further encompasses methods and systems, including network-based processes, to manage the SNP data and other data relating to specific animals and herds of animals, veterinarian care, diagnostic and quality control data and management of livestock which, based on genotyping, have predictable meat quality traits, husbandry conditions, animal welfare, food safety information, audit of existing processes and data from field locations.