Faecal Mimic Composition for Ileostomy Rehabilitation
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Solution Overview
Problem
Patients with temporary bypass ileostomy often experience severe defecatory dysfunction due to the interruption of intestinal transit, leading to dysbiosis, mucosal atrophy, and neuromuscular atrophy, with no existing method capable of restoring functional faeces formation and physiological defecatory function.
Innovation Solution
A composition comprising different types of soluble fibre, including prebiotic oligosaccharides, cellulose derivatives, and humectants, is administered through the distal orifice of the ileostomy to restore functional faeces production and physiological defecatory function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a bypass ileostomy is performed to protect an intestinal anastomosis, then the risk of dehiscence and complications is reduced, but defecatory dysfunction, dysbiosis, and mucosal atrophy occur due to interrupted faecal transit
Solution Approach 1:
The patent introduces an intermediary substance (faecal mimic composition) that mediates between the interrupted faecal stream and the excluded colorectal segment. This composition mimics the physical and chemical properties of natural faeces, providing mechanical stimulation and nutritional substrate without requiring actual faecal passage through the protected anastomosis site.
Solution Approach 2:
The excluded colorectal segment serves itself by receiving the faecal mimic composition through the distal ileostomy orifice, maintaining its own function (peristalsis, mucosal health) independently from the proximal faecal stream. The composition enables the distal segment to sustain itself without compromising the proximal anastomosis.
2Reliability
If faecal transit is interrupted at the ileostomy level, then anastomotic protection is achieved, but the colorectal mucosa undergoes atrophy and inflammation due to lack of nutritional substrate
Solution Approach 1:
The faecal mimic composition acts as an intermediary that delivers nutritional substrate (short-chain fatty acids, fibre) to the excluded mucosa without requiring faecal passage through the vulnerable anastomosis. This mediator maintains mucosal health while preserving anastomotic protection.
Solution Approach 2:
The invention changes the parameter of substrate delivery by using a controlled composition with specific fibre content, short-chain fatty acid concentration, and osmolarity that can be administered through the distal orifice, transforming the problem of complete transit interruption into a controlled delivery system.
3Reliability
If intestinal transit reconstruction is delayed until after adjuvant treatment, then cancer treatment protocols are followed, but dysbiosis and functional alterations worsen over time
Solution Approach 1:
The patent applies preliminary action by implementing rehabilitation with the faecal mimic composition during the period when transit must remain interrupted for cancer treatment. This preliminary rehabilitation maintains colorectal function and prevents severe dysbiosis during the unavoidable interruption period, facilitating smoother transition when reconstruction eventually occurs.
4Ease of operation
If external prostheses or manual instillation of intestinal chyme are used to re-establish transit continuity, then some faecal formation may be achieved, but the composition lacks the necessary fibre content and biological activity to restore normal defecatory function
Solution Approach 1:
The invention optimizes parameters by formulating a composition with specific fibre content (10-30%), short-chain fatty acid concentration, osmolarity, and pH that mimics natural faeces more closely than previous attempts. These parameter changes enable the composition to provide adequate mechanical stimulation and nutritional substrate for reliable defecatory function restoration.
Solution Approach 2:
The patent uses a composite material comprising multiple components (fibre, short-chain fatty acids, electrolytes, buffer agents) that work synergistically to restore defecatory function. This composite approach addresses the limitations of single-substance instillation methods by combining mechanical, nutritional, and physiological functions in one formulation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively restores the production of biologically active faeces, re-establishes intestinal peristalsis and defecatory function, and maintains normal intestinal microbiota, thereby preventing atrophy and inflammation of the colorectal mucosa.
Implementation Method 1
the lack of intestinal contents in contact with the mucosa prevents nutrition of the colonocytes, which depends on short-chain fatty acids (butyrate, propionate and acetate) produced by the bacterial flora when fermenting the undigested fibre in previous sections
Implementation Method 2
A composition comprising different types of soluble fibre, including prebiotic oligosaccharides, cellulose derivatives, and humectants
Implementation Method 3
comprising different types of soluble fibre, namely at least one prebiotic oligosaccharide and one soluble cellulose derivative
Data Source
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AI summary
The present invention relates to a composition for re-establishing the formation of functional faeces and restoring the bowel function in patients with temporary derivative ileostomy, said composition based on soluble fibres and comprising at least one prebiotic oligosaccharide and a soluble cellulose derivative.