Percutaneous False Lumen Stabilization for Aortic Dissection
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Solution Overview
Problem
Aortic dissection, characterized by the separation of the aortic wall layers leading to a false lumen, results in impaired blood flow and perfusion of vital structures, posing a life-threatening emergency with limited effective treatment options beyond surgery.
Innovation Solution
A percutaneous method involving the use of a stabilization agent to fill and seal the false lumen, utilizing expandable devices, aspiration, and delivery of fillers such as fibers, coils, and adhesives to stabilize and remodel the aortic structure, reducing the volume of the false lumen and promoting blood flow through the true lumen.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If surgery is performed to repair aortic dissection, then the effectiveness of treatment is improved, but the invasiveness and recovery time increase
Solution Approach 1:
The treatment device segments the aorta into true lumen and false lumen regions, allowing targeted intervention in the false lumen while preserving true lumen flow. The filler material is delivered selectively into the false lumen through a catheter system, separating the treatment zone from the healthy tissue.
Solution Approach 2:
A catheter-based delivery system acts as an intermediary to transport filler material into the false lumen percutaneously. This intermediate device enables the treatment to be performed through a minimally invasive approach rather than requiring direct surgical access to the aorta.
2Object-affected harmful factors
If the false lumen volume is reduced through percutaneous filling, then the risk of rupture is reduced, but the device complexity increases
Solution Approach 1:
The false lumen volume is reduced by changing the physical state of the filler material from liquid to solid upon delivery. The liquid filler is injected through the catheter and then solidifies in situ, occupying space in the false lumen and reducing its volume without requiring complex mechanical compression devices.
Solution Approach 2:
The filler material is a composite composition designed to be injectable in liquid form and then solidify to provide structural support. This composite approach combines the benefits of easy delivery (liquid state) with effective volume reduction and structural reinforcement (solid state), simplifying the overall device design.
3Loss of time
If percutaneous stabilization agent delivery is used, then the recovery time is reduced, but the manufacturing precision requirements increase
Solution Approach 1:
The filler material self-solidifies upon delivery into the false lumen, eliminating the need for complex external control systems or precise positioning mechanisms. The material's inherent phase-changing property performs the stabilization function automatically, reducing manufacturing precision requirements for the delivery device.
Data Source
AI summary
The methods and devices disclosed herein pertain to the percutaneous treatment of various forms of aortic dissection by at least partially filling the false lumen of the aortic dissection with a stabilization agent percutaneously and steps to decrease the size of the false lumen using the devices. Fluid maybe aspirated from the false lumen to decrease the volume of the false lumen. And the entrance opening between the true lumen and the false lumen may be sealed with a sealing agent such as a biocompatible adhesive. The medical devices disclosed herein generally comprise an extendable sealing element that is used in conjunction with a catheter to expand the true lumen while reducing the size of the false lumen. The device has the ability to aspirate and/or deliver fluid containing the stabilization agent into the false lumen.