Multi-wavelength Faraday Wave Assembly for Complex Cell Structures

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Solution Overview

Problem

Existing Faraday wave biological assembly technologies are limited to single-wavelength cell assembly, failing to construct multi-scale, complex, and arbitrary cell structures, which are necessary for advanced tissue engineering applications.

Innovation Solution

A method for multi-wavelength synthesis of Faraday waves is developed by combining sine or cosine signals with different wavelengths, allowing for the creation of complex acoustic pressure fields that enable the construction of multi-scale, complex cell structures through the superposition of sine or cosine waves, using a Fourier series to simplify complex patterns into a series of waves.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If single-wavelength Faraday wave assembly is used, then the system is simple and easy to operate, but it can only construct simple geometric shapes and limited cell structures

Engineering Contradiction:
Improveease of operationVSAvoidcell structure diversity
Core Design Contradiction:
Ease of operationVSAdaptability or versatility

Solution Approach 1:

The patent combines multiple single-wavelength Faraday wave assemblies into a multi-wavelength synthesis system. By superimposing multiple sine or cosine signals with different wavelengths, the system achieves complex cell pattern formation while maintaining the simplicity of individual Faraday wave components. This merging approach allows the system to construct multi-scale, complex, and arbitrary cell structures without fundamentally changing the operational simplicity of the underlying Faraday wave mechanism.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent segments the complex cell structure formation into multiple independent wavelength components. Each wavelength corresponds to a specific spatial frequency that can be independently controlled through separate sine or cosine signals. This segmentation allows the system to build complex patterns by combining simple, controllable wavelength components, thereby maintaining ease of operation while achieving high versatility in cell structure construction.

Inventive Principle:
Principle #1Segmentation

2Adaptability or versatility

If acoustic holography technology is used, then complex and arbitrary cell structures can be constructed, but the system becomes complex and the operation process becomes complicated

Engineering Contradiction:
Improvecell structure diversityVSAvoidsystem complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent replaces the complex acoustic holography system with a simplified Faraday wave-based mechanical system. Instead of using complex acoustic field manipulation, the invention uses mechanical vibration at specific frequencies to generate Faraday waves that directly organize cells into desired patterns. This substitution maintains the ability to construct complex cell structures while significantly reducing system complexity and operational difficulty.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent changes the control parameters from complex acoustic field parameters to simpler mechanical vibration frequencies. By controlling the frequency and amplitude of mechanical vibrations that generate Faraday waves, the system achieves the same cell structure formation capability as acoustic holography but with much simpler parameter control. This parameter transformation simplifies the system while maintaining versatility in cell pattern construction.

Inventive Principle:
Principle #35Parameter changes

3Device complexity

If single-wavelength assembly mode is used, then the system is simple, but it fails to meet the requirements of constructing multi-scale, complex and arbitrary cell structures

Engineering Contradiction:
Improvesystem simplicityVSAvoidcell structure complexity
Core Design Contradiction:
Device complexityVSManufacturing precision

Solution Approach 1:

The patent adds the wavelength dimension to the Faraday wave assembly system. By introducing multiple wavelengths simultaneously through signal synthesis, the system transitions from single-scale to multi-scale cell structure construction. This dimensional expansion in the frequency domain enables the formation of complex, multi-scale patterns while keeping each individual wavelength component simple and easy to control.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method expands the capabilities of Faraday wave assembly to form complex and arbitrary patterns of multi-scale cells, enhancing biocompatibility and applicability in tissue engineering by allowing the construction of intricate tissue structures like the liver and other organs with specific multi-scale units.

Implementation Method 1

the liquid-bottom cells are subjected to the combined actions of acoustic pressure, buoyancy and gravity, wherein the acoustic pressure plays a decisive role in a cell's equilibrium position

Methodology Applied
Scientific EffectAcoustic pressure: Acoustic Radiation Pressure

Implementation Method 2

the liquid-bottom cells are subjected to the combined actions of acoustic pressure, buoyancy and gravity

Methodology Applied
Scientific EffectBuoyancy: Archimedes' Principle (Buoyancy)

Implementation Method 3

the liquid-bottom cells are subjected to the combined actions of acoustic pressure, buoyancy and gravity

Methodology Applied
Scientific EffectGravity: Gravitation

Implementation Method 4

transferring the amplified fidelity electric signal to a vibration exciter to generate stable and periodic vibration

Methodology Applied
Scientific EffectVibration: Vibration

Implementation Method 5

Faraday wave biological assembly technology has advantages such as easy system construction, simple operation, dynamically adjustable patterns

Methodology Applied
Scientific EffectFaraday wave: Faraday Wave

Data Source

PatentUS20240344049A1Bioassembly method for synthesis using multiwavelength faraday waves and use thereof
Publication Date: 2024.10.17 SHENZHEN CONVERGENCE BIO MFG CO LTD
  • US20240344049A1 patent drawing
  • US20240344049A1 patent drawing
  • US20240344049A1 patent drawing

AI summary

Provided are a biological assembly method for Faraday wave multi-wavelength synthesis and an application. The present method has advantages that the system is easy to build, manipulation is simple, patterns are dynamically adjustable, biocompatibility is good, etc. The present method is different from a cell manipulation principle under a single wavelength condition in an existing acoustic biological assembly method; sine or cosine signals having different wavelengths are synthesized, so that a single-wavelength assembly mode in a conventional Faraday wave frequency domain is improved into a multi-wavelength assembly mode, complex and arbitrary pattern arrangement of liquid-bottom multi-scale cells is achieved, and thus the method is more suitable for the requirement for complex arrangement of cells in tissue engineering and biological manufacturing, and has huge application prospects and commercial value.