Fast Dissolving Tablet via Dual-Solution Granulation
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Solution Overview
Problem
Existing fast dissolving tablets face challenges with high production costs, insufficient mechanical strength, and inadequate disintegration speed, making them unsuitable for elderly and children, and difficult to package effectively.
Innovation Solution
A fast dissolving tablet composition comprising a pharmaceutically active ingredient, starch, hydrophilic polymer, surfactant, and excipients, prepared through a process involving the blending of two solutions followed by granulation and compression-molding, which enhances rapid disintegration and mechanical strength while reducing costs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If freeze-drying method is used to prepare fast dissolving tablet, then dissolution rate is improved, but manufacturing cost increases and mechanical strength becomes insufficient
Solution Approach 1:
The patent changes the physical and chemical parameters of the tablet formulation by incorporating specific excipients (sugar alcohols, saccharides, disintegrants) and adjusting their proportions to achieve rapid dissolution without requiring freeze-drying. The tablet hardness is optimized to balance disintegration speed and mechanical strength, resolving the contradiction between dissolution rate and manufacturing cost.
Solution Approach 2:
The patent uses composite materials consisting of multiple excipients (sugar alcohol, saccharide, disintegrant) combined with the active pharmaceutical ingredient. This composite formulation achieves rapid dissolution through synergistic effects while maintaining adequate mechanical strength and avoiding the need for expensive freeze-drying processes.
2Speed
If freeze-drying method is used to prepare fast dissolving tablet, then dissolution rate is improved, but mechanical strength becomes insufficient
Solution Approach 1:
The patent employs composite materials with multiple excipients (sugar alcohol, saccharide, disintegrant) that work synergistically to provide both rapid dissolution and adequate mechanical strength. The disintegrant component specifically addresses the strength issue by creating a foam structure that facilitates rapid water penetration while maintaining tablet integrity during handling.
Solution Approach 2:
The patent creates a porous tablet structure through the action of disintegrants that generate gas bubbles during disintegration. This porous structure allows rapid water penetration and dissolution while the overall tablet maintains sufficient mechanical strength for packaging and handling through proper formulation and compression.
3Shape
If heating and melting method is used to prepare porous tablet, then porous structure is achieved, but compatibility scope of medicament decreases and disintegrating ability deteriorates
Solution Approach 1:
The patent avoids heating and melting by using alternative methods to create porous structure. Instead, it employs disintegrants that react with water or carbon dioxide to generate gas bubbles, creating porosity at lower temperatures that preserve medicament compatibility and disintegrating ability.
Solution Approach 2:
The patent uses disintegrants as intermediary substances that facilitate porous structure formation without requiring direct heating of the medicament. These disintegrants act as mediators that generate gas bubbles to create porosity while maintaining compatibility with a broad range of medicaments.
4Strength
If high compression molding pressure is used to increase tablet hardness, then mechanical strength is improved, but disintegration speed decreases
Solution Approach 1:
The patent uses composite materials where disintegrants are incorporated into the formulation. These disintegrants create an internal foam structure that facilitates rapid water penetration and disintegration even when tablets are compressed at high pressures to achieve adequate mechanical strength for packaging.
Solution Approach 2:
The patent creates a porous internal structure through disintegrant action that remains accessible to water even in highly compressed tablets. The porous structure allows rapid water penetration and disintegration while the external tablet maintains sufficient hardness for handling and packaging.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The tablets achieve rapid disintegration in under 1 minute, sufficient mechanical strength for packaging, and low brittleness, making them suitable for elderly and children, and cost-effective to produce.
Implementation Method 1
the hydrophilic polymer having strong water absorption
Implementation Method 2
the dissolution rate of tablets is improved by the surfactant in an oral cavity
Data Source
AI summary
The present invention provides a method for making a fast dissolving tablet. The method includes the steps of (a) preparing a first solution containing a hydrophilic polymer and a starch; (b) preparing a second solution containing a pharmaceutically active ingredient and a surfactant; (c) blending the first and the second solution together to form a plurality of granule powders by granulation; (d) mixing the granule powders with excipients; and (e) applying a compression-molding process to form the fast dissolving tablet.