Fat-Soluble Nutrient Stabilization via Aqueous Polymer Evaporation
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Solution Overview
Problem
Existing formulations of fat-soluble nutrients face challenges in achieving stability, solubility, and bioavailability due to their poor solubility in water and chemical instability, limiting their use in aqueous environments and requiring specialized equipment for preparation.
Innovation Solution
A process involving the addition of a solution of fat-soluble nutrients and antioxidants in an organic solvent to an aqueous polymer phase, followed by evaporation to create a stable, amorphous microparticulate mixture, which can be further layered onto an inert core to form solid beadlets, utilizing water-soluble polymers and nutraceutically acceptable excipients to enhance stability and dispersibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If fat soluble nutrients are formulated in aqueous environments, then bioavailability and solubility are improved, but chemical stability deteriorates due to their inherent lipophilic nature
Solution Approach 1:
The patent employs water-soluble polymers (hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, or xanthan gum) as intermediary substances that bridge the lipophilic fat-soluble nutrients and the aqueous environment. These polymers form a stabilizing matrix that allows the nutrients to disperse in water while maintaining their integrity and preventing direct exposure to destabilizing aqueous conditions, thus simultaneously improving bioavailability and maintaining chemical stability.
Solution Approach 2:
The formulation creates a composite system combining fat-soluble nutrients with water-soluble polymers and excipients. This composite structure allows the hydrophilic polymer matrix to provide aqueous compatibility and stability while entrapping the lipophilic nutrients, enabling the system to exhibit properties of both components - water solubility from the polymer and nutrient delivery from the fat-soluble compound.
2Stability of the object's composition
If specialized equipment is used for preparation, then formulation stability is improved, but manufacturing complexity and cost increase
Solution Approach 1:
The formulation is designed to self-stabilize through the inherent properties of the water-soluble polymers and excipients combination. The polymers form a protective matrix that automatically stabilizes the fat-soluble nutrients upon contact with aqueous environments, eliminating the need for specialized stabilization equipment or complex processing conditions. The system self-regulates to maintain stability through the natural gel-forming and protective properties of the polymer-excipient matrix.
3Ease of manufacture
If conventional formulation methods are used, then manufacturing simplicity is maintained, but solubility and dispersibility in water are insufficient
Solution Approach 1:
The patent fundamentally changes the formulation parameters by selecting specific water-soluble polymers with gel-forming capabilities and combining them with particular excipients in optimized ratios. This parameter change transforms the formulation from a simple mixture to a structured gel matrix that inherently provides water solubility and dispersibility. The modified formulation parameters enable conventional manufacturing equipment to produce a formulation with significantly enhanced aqueous compatibility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting compositions are stable, soluble, and dispersible in water, suitable for various health applications, including eye, skin, and brain health, and can be formulated into different dosage forms using common industrial equipment, overcoming the limitations of previous methods.
Implementation Method 1
A process for preparation of a stabilized composition is described herein, where a solution of fat soluble nutrient(s) and antioxidant(s) in organic solvent are added to an aqueous polymer phase and then subjected to evaporation to obtain a significantly amorphous microparticulate mixture.
Implementation Method 2
a solution of fat soluble nutrients and at least one nutraceutically acceptable excipient in organic solvent is added to an aqueous polymer phase, homogenized
Data Source
AI summary
A stabilized composition of fat soluble nutrient(s) includes a water soluble polymer and at least one nutraceutically acceptable excipient. The composition can be in the form of significantly amorphous aqueous microparticulate mixtures or as a solid beadlet product. A process for preparation of a stabilized composition includes a fat soluble nutrient solubilized in an organic solvent embedded in an aqueous polymer phase by evaporation, so as to obtain an aqueous microparticulate mixture. This mixture is stable, soluble and can be formulated for end use or can be layered on inert core for example to obtain stable beadlet(s) for use in solid dosage forms. Such stabilized aqueous microparticulate and solid beadlet compositions exhibit good solubility and dispersibility. Stabilized compositions of fat soluble nutrients can be prepared using industrially convenient equipment and can be formulated as per requirement for use in health applications.