Fatty Acid Membrane Formulation for Long-Lasting Pain Relief

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Solution Overview

Problem

Current oral and topical pain medications fail to address the root cause of pain and have significant safety concerns, while topical preparations only provide temporary relief and do not penetrate beyond the outermost layer of the epidermis.

Innovation Solution

A formulation comprising specific ratios of fatty acids and additional ingredients that mimic the composition of cell membranes, allowing penetration and modulation of membrane functions to address pain and other cellular imbalances, including the induction of pluripotent stem cells without viral vectors.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If current topical pain medications are used, then temporary pain relief is achieved, but penetration beyond the outermost layer of epidermis is limited

Engineering Contradiction:
Improveduration of pain reliefVSAvoidpenetration depth
Core Design Contradiction:
Duration of action of moving objectVSLength of stationary object

Solution Approach 1:

The patent changes the chemical parameters of the delivery system by using fatty acid formulations with specific chain lengths and saturation levels that match cell membrane composition. This allows the formulation to penetrate beyond the epidermis while maintaining biocompatibility and extended duration of action through membrane integration.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs a composite formulation combining multiple fatty acids (saturated and unsaturated) in specific ratios to create a material that can both penetrate skin barriers and integrate with cell membranes. This composite approach enables simultaneous achievement of deep penetration and prolonged therapeutic effect.

Inventive Principle:
Principle #40Composite materials

2Reliability

If oral pain medications are used, then pain relief is achieved, but significant safety concerns and side effects occur

Engineering Contradiction:
Improvesafety profileVSAvoidside effects
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent uses fatty acids as intermediary molecules that deliver therapeutic effects through membrane integration rather than through systemic pharmacological action. This intermediary approach allows pain relief and anti-inflammatory effects without the harmful side effects of traditional oral medications, as the fatty acids naturally occur in cell membranes and are metabolized through normal lipid pathways.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Adaptability or versatility

If current pain medications are used, then some aspects of pain are addressed, but the root cause of pain remains untreated

Engineering Contradiction:
Improvescope of pain managementVSAvoidroot cause treatment
Core Design Contradiction:
Adaptability or versatilityVSReliability

Solution Approach 1:

The patent creates a universal fatty acid formulation that simultaneously addresses multiple aspects of pain pathophysiology: membrane stabilization, anti-inflammatory effects, pain signal modulation, and tissue healing. By targeting the root cause of pain through membrane composition correction, the formulation provides comprehensive pain management rather than symptomatic relief alone.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The formulation effectively penetrates beyond the epidermis, provides long-lasting pain relief, improves wound healing, and modulates cellular functions to address the root cause of pain and other chronic diseases.

Implementation Method 1

The formulations may, e.g., supply a component(s) to correct a deficiency in a cell membrane composition... The formulations comprise a mixture of fatty acids in specific ratios such that the formulation may cross, integrate, modulate, regulate, or restore a function(s) of a membrane of a cell

Methodology Applied
Scientific EffectPermeation: Permeation

Implementation Method 2

The fatty acid composition of the formulation renders the formulation capable of one or more of the following: crossing, integrating, modulating, regulating, or restoring the membrane's function(s)

Methodology Applied
Scientific EffectLipid incorporation: Absorption (physical)

Data Source

PatentUS12414993B2Formulations and uses thereof
Publication Date: 2025.09.16 MA JOYCE H
  • US12414993B2 patent drawing
  • US12414993B2 patent drawing
  • US12414993B2 patent drawing

AI summary

Preparations and formulations capable of crossing and incorporating into a membrane of a cell or an organelle or an exosome are described. Methods of treatments utilizing the preparations and formulations are also described.