Fatty Acid Mixture for Alopecia Treatment via SRD5A Inhibition

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Solution Overview

Problem

Current treatments for androgenetic alopecia lack efficacy and safety, particularly in inhibiting SRD5A1, SRD5A2, and SRD5A3 gene expression, and require higher dosages with potential toxicity, while existing methods for preparing fatty acid compositions are inefficient and environmentally unfriendly.

Innovation Solution

A fatty acid mixture comprising caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, oleic acid, and linolenic acid, isolated from natural sources like olive or sunflower oil, which effectively inhibits SRD5A1, SRD5A2, and SRD5A3 gene expression, and is formulated into pharmaceutical or cosmetic compositions with low toxicity and improved manufacturing processes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If higher dosages of fatty acid compositions are used to improve treatment efficacy, then the effectiveness in inhibiting SRD5A1, SRD5A2, and SRD5A3 gene expression increases, but toxicity increases

Engineering Contradiction:

Improvetreatment efficacyVSAvoidtoxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent optimizes the concentration ratios of specific fatty acids (caprylic, capric, lauric, myristic, palmitic, oleic, and linolenic acid) within the composition to achieve maximum efficacy at lower dosages, thereby reducing toxicity while maintaining treatment effectiveness

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses a composite mixture of multiple fatty acids with specific concentration ranges (caprylic acid 2-5%, capric acid 2-5%, lauric acid 30-50%, myristic acid 10-20%, palmitic acid 4-10%, oleic acid 20-33%, linolenic acid 1-10%) to achieve synergistic effects that improve efficacy while reducing individual component toxicity

Inventive Principle:

Principle #40Composite materials

2Ease of manufacture

If organic solvent extraction technology is used to obtain fatty acid compositions, then the extraction process is simple, but the yield is very low and the process is environmentally unfriendly

Engineering Contradiction:

Improveextraction simplicityVSAvoidextraction yield

Core Design Contradiction:

Ease of manufactureVSProductivity

Solution Approach 1:

The patent replaces organic solvent extraction with alternative extraction methodologies that eliminate the need for harmful solvents while significantly improving extraction yield and environmental sustainability, maintaining process simplicity through innovative extraction techniques

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Reliability

If camel hump fat is used as a source of fatty acids, then the composition contains relevant fatty acids for hair growth, but the source is not readily available and dosages are not optimized

Engineering Contradiction:

Improvehair growth efficacyVSAvoidsource availability

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent extracts and isolates the specific beneficial fatty acids (caprylic, capric, lauric, myristic, palmitic, oleic, and linolenic acid) from readily available sources, separating the active ingredients from the unavailable camel hump fat matrix while maintaining the effective concentration ratios for hair growth treatment

Inventive Principle:

Principle #2Taking out (Extraction)

Data Source

PatentEP4082518A1Fatty acid compositions for the treatment and prevention of hair loss and alopecia

Publication Date: 2022.11.02 CNCE INNOVACION

AI summary

The present invention related to fatty acid mixture with improved efficacy and inhibited gene expression of SRD5A1, SRD5A2 and SRD5A3 as well as compositions thereof suitable for the treatment and/or prevention of hair loss and alopecia, notably with lower dosage and low toxicity. Furthermore, the present invention also relates to the process to obtain said mixtures and composition and to the use of said compositions for the treatment and/or prevention of androgenetic alopecia (AGA) and /or hair loss.