Fatty Acid-Mediated Peptide Delivery in Skin Care Creams

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Solution Overview

Problem

Some peptide derivatives, such as Caffeoyl Hexapeptide 9, face difficulty in penetrating into the skin, especially from cream compositions containing higher amounts of oily components.

Innovation Solution

A cosmetic skin care composition comprising a peptide derivative with a specific formula, a fatty acid with 8 to 22 carbon atoms, and a dermatologically acceptable carrier, formulated at a preferred ratio and level, enhances skin penetration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If peptide derivatives are used in cream compositions with higher amounts of oily components, then skin moisturization and cream stability are improved, but peptide penetration into skin deteriorates

Engineering Contradiction:

Improvecream stabilityVSAvoidpeptide penetration

Core Design Contradiction:

Stability of the object's compositionVSReliability

Solution Approach 1:

The patent introduces a penetration enhancer as an intermediary substance that facilitates peptide derivative penetration through the skin barrier. The penetration enhancer mediates between the oily cream composition and the peptide, enabling effective delivery without compromising cream stability. This resolves the contradiction by providing a bridging mechanism that allows both high oil content for stability and effective peptide penetration.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Adaptability or versatility

If peptide derivatives are used in cream compositions with higher amounts of oily components, then cream formulation flexibility is improved, but peptide delivery efficiency deteriorates

Engineering Contradiction:

Improveformulation flexibilityVSAvoidpeptide delivery efficiency

Core Design Contradiction:

Adaptability or versatilityVSProductivity

Solution Approach 1:

The penetration enhancer serves as a mediator that enables effective peptide delivery across various cream formulations with different oil contents. This allows formulators to maintain flexibility in creating diverse cream compositions while ensuring consistent peptide delivery efficiency through the mediating action of the penetration enhancer.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent optimizes parameters including the concentration ratio of peptide derivative to penetration enhancer (1:1 to 1:100), the carbon chain length of the penetration enhancer (C8-C22), and pH conditions (pH 3-7) to maximize peptide delivery efficiency while maintaining formulation flexibility. These parameter optimizations enable effective peptide delivery across various cream formulations.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS20250332083A1Skin care composition comprising peptide derivative and fatty acid, and method of using the same

Publication Date: 2025.10.30 PROCTER & GAMBLE CO

AI summary

A cosmetic skin care composition having a peptide derivative, a fatty acid having from about 8 to about 22 carbon atoms, and a dermatologically acceptable carrier. The peptide derivative has a formula: Rc-R1-Gly-Pro-Gln-Gly-R2, where Rc is chosen from hydroxycinnamic acid, its derivative, and mixtures thereof, where R1 and R2 are respectively from about 0 to about 8 amino acids, and wherein a total of R1 and R2 is 8 or less amino acids; The composition provides improved penetration of such peptide derivatives to skin.