Non β-Oxidizable Fatty Acid and Protein Composition for Metabolic Disorders
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Solution Overview
Problem
Current treatments and preventions for insulin resistance, obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia, atherosclerosis, and other metabolic disorders are not sufficiently effective, and existing animal feeds do not adequately modify fatty acid composition for improved animal health and body composition.
Innovation Solution
A composition combining non β-oxidizable fatty acid entities with a protein material, specifically tetradecylthioacetic acid (TTA) and a fermented soy protein material, which are incorporated into animal feed to alter fatty acid metabolism and improve health outcomes by increasing fatty acyl CoA oxidase activity and lowering plasma cholesterol and triglycerides.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If non β-oxidizable fatty acid entities are used alone for treatment, then some therapeutic effect is achieved, but the effectiveness is insufficient for metabolic disorders
Solution Approach 1:
The patent combines non β-oxidizable fatty acid entities with protein materials to create a composite composition that produces synergistic effects. The fatty acid entities (such as TTA) work together with protein materials to enhance fatty acid oxidation, lower plasma cholesterol and triglycerides more effectively than either component alone, and improve overall therapeutic effectiveness for metabolic disorders.
2Quantity of substance
If existing animal feeds are used, then animals receive basic nutrition, but fatty acid composition is not adequately modified for improved health
Solution Approach 1:
The patent modifies the fatty acid composition of animal feed by incorporating non β-oxidizable fatty acid entities that alter metabolic parameters. These compounds change the fatty acid profile in animal tissues, increase fatty acid oxidation rates, and modify plasma lipid composition, thereby improving animal health outcomes beyond basic nutritional requirements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination significantly reduces plasma cholesterol, triglycerides, and phospholipids levels, enhances fatty acid oxidation, and shows synergistic effects in preventing and treating metabolic disorders, while also improving the fatty acid composition and body composition of animals fed with the modified feed.
Implementation Method 1
compounds comprising non β-oxidizable fatty acid entities
Implementation Method 2
increase fatty acyl CoA oxidase activity
Implementation Method 3
lowers the concentration of plasma cholesterol, triglycerides and phospholipids
Data Source
AI summary
The present invention concerns a composition prepared from a combination of non β-oxidizable fatty acid entities and a protein material, and the use of said composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of insulin resistance, obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders. An alternative embodiment of the invention includes oil in the composition The present invention also concerns an animal feed prepared from a combination of a protein material and a compound comprising non β-oxidizable fatty acid analogues, the use of said feed for improving the body composition of an animal, and a product produced from said animal.