Fatty Alcohol Personal Care Compositions for Selective Bacterial Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current personal care compositions, such as antiperspirant/deodorant compositions, are ineffective in selectively inhibiting the growth of detrimental bacteria like Corynebacteria while promoting the growth of beneficial bacteria like Staphylococcus epidermidis, leading to undesirable underarm odors.
Innovation Solution
Incorporating specific fatty alcohols, such as 2-butyl octanol, in effective amounts within personal care compositions to selectively inhibit detrimental bacteria and promote beneficial bacteria, thereby reducing odor-causing bacteria and enhancing antimicrobial peptide production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional personal care compositions are used, then general antimicrobial activity is provided, but selective inhibition of detrimental bacteria while promoting beneficial bacteria is not achieved
Solution Approach 1:
The patent applies local quality by using fatty alcohols with specific chain lengths (C12-C45) that exhibit selective antimicrobial activity against different bacterial types. The fatty alcohols are tailored to have specific properties (chain length, branching) that enable them to differentially affect Corynebacteria versus Staphylococcus bacteria, creating localized selective pressure on the bacterial population.
Solution Approach 2:
The patent employs parameter changes by varying the fatty alcohol chain length (C12-C45), degree of branching, and concentration to achieve selective bacterial control. By adjusting these parameters, the composition can preferentially inhibit detrimental Corynebacteria while allowing or promoting beneficial Staphylococcus growth, thereby resolving the contradiction between general antimicrobial activity and selective bacterial control.
2Quantity of substance
If broad-spectrum antimicrobials are used to reduce all bacteria, then bacterial load is reduced, but beneficial bacteria are also inhibited
Solution Approach 1:
The fatty alcohols are designed with specific local qualities (chain length C12-C45, branching patterns) that create differential effects on bacterial populations. These specific molecular properties enable the composition to selectively interact with detrimental bacteria versus beneficial bacteria, reducing the former while preserving or promoting the latter.
Solution Approach 2:
The patent uses composite fatty alcohol structures with specific chain lengths and branching patterns that work synergistically to achieve selective bacterial control. The composite nature of these tailored fatty alcohols, combined with their specific concentration ranges, creates a multi-faceted approach to differential bacterial inhibition and promotion.
Data Source
AI summary
Compositions, such as personal care compositions, and methods for selectively inhibiting the growth of a detrimental bacteria and promoting the growth of a beneficial bacteria are disclosed. The composition may include a base and one or more fatty alcohols. The one or more fatty alcohols may be present in an amount effective to selectively inhibit the growth of at least one detrimental Gram-positive bacteria and promote the growth of at least one beneficial Gram-positive bacteria on skin. The detrimental Gram-positive bacteria may include Corynebacterium, and the beneficial Gram-positive bacteria may include Staphylococcus.