Feed Additive Combinations for Oxidative Stress Reduction
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Solution Overview
Problem
High-producing and growing animals are prone to oxidative stress due to excessive free radicals, which can be exacerbated by dietary factors, leading to compromised health and production performance, and existing antioxidant sources may not be equally effective in addressing this issue.
Innovation Solution
A combination of antioxidants such as 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline, tertiary butyl hydroquinone, and butylated hydroxyanisole, along with organic trace minerals and organic acids, is provided to animals to reduce oxidative stress and improve health and production performance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Use of energy by moving object
If dietary lipids are supplemented to improve animal performance, then energy intake increases, but free radical accumulation and oxidative stress increase
Solution Approach 1:
The patent applies this principle by using dietary lipids that initially cause oxidative stress but transforming them into beneficial components through stabilization with specific antioxidants. The harmful free radicals generated by lipid metabolism are counteracted by combining lipids with antioxidants like ethoxyquin, BHA, BHT, and tocopherols, converting the harmful oxidative effect into a beneficial energy source without damage.
Solution Approach 2:
The patent creates composite feed formulations combining dietary lipids with multiple antioxidants (ethoxyquin, BHA, BHT, tocopherols) and organic trace minerals. This composite approach allows the lipid to provide energy while the antioxidant combination prevents oxidative damage, resolving the contradiction between energy intake and oxidative stress.
2Reliability
If inorganic trace minerals are used to improve antioxidant status, then immune response improves, but bioavailability is limited due to dietary antagonisms
Solution Approach 1:
The patent changes the chemical form of trace minerals from inorganic to organic complexes. By binding trace minerals to organic ligands such as amino acids, hydroxy acids, and carboxylic acids, the patent alters the physical-chemical parameters of the minerals to improve their solubility, stability, and bioavailability while maintaining their immune-supporting functions.
Solution Approach 2:
The patent introduces organic ligands (amino acids, hydroxy acids, carboxylic acids) as intermediaries between the trace minerals and the animal's metabolic systems. These intermediaries facilitate better absorption and utilization of trace minerals by reducing dietary antagonisms and improving bioavailability, thereby enhancing immune response.
3Reliability
If multiple antioxidants are combined to improve antioxidant capacity, then oxidative stress protection increases, but formulation complexity increases
Solution Approach 1:
The patent merges multiple antioxidants (ethoxyquin, BHA, BHT, tocopherols) into a single integrated feed formulation. By combining these antioxidants with dietary lipids and organic trace minerals in specific ratios, the patent creates a unified composition that provides synergistic antioxidant protection while simplifying the feeding process compared to administering separate antioxidant supplements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination effectively reduces oxidative stress, improves antioxidant status, and enhances production performance by stabilizing dietary lipids and supporting the endogenous antioxidant defense mechanism in animals.
Implementation Method 1
Dietary antioxidants are useful for preventing the oxidation of dietary lipids in the final feed and for reducing free radical damage
Implementation Method 2
The organic trace mineral comprises a metal chelate or a metal salt comprising at least one metal ion and at least one ligand
Data Source
AI summary
The present invention provides combinations of dietary supplements and methods of using of these combinations to improve the health and production performance of animals. In particular, the combinations of the invention comprise antioxidants, trace minerals, organic acids, essential amino acids, and mixtures thereof.