Feed Additive Composition with Xylanase and Beta-Glucanase

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Solution Overview

Problem

The challenge lies in effectively utilizing high-fiber, low-nutritive alternative ingredients in animal feeds, particularly for poultry and swine, as they contain non-starch polysaccharides that are indigestible and limit nutrient intake, necessitating technologies to efficiently break down dietary fiber and mitigate anti-nutritional properties.

Innovation Solution

Combining specific direct-fed microbials (DFMs) with xylanase and β-glucanase enzymes to optimize the degradation of plant cell wall components, particularly hemicellulose, into short-chain fatty acids (SCFAs) in the gastrointestinal tract, enhancing energy utilization and nutrient absorption.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If alternative high-fiber ingredients are used in animal feeds, then cost-effectiveness is improved, but digestibility and nutrient utilization deteriorate due to high non-starch polysaccharide content

Engineering Contradiction:
Improvecost-effectivenessVSAvoiddigestibility
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The patent combines multiple enzymes (xylanase, β-glucanase, cellulase) with direct-fed microbials (probiotics) into a single feed additive composition. This merging creates a synergistic system where enzymes provide immediate hydrolysis of non-starch polysaccharides while microbials contribute to sustained digestion and gut health, thereby improving digestibility without sacrificing the cost-effectiveness of using alternative ingredients.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite feed additive composition containing both enzymatic and microbial components. The composite structure allows the product to address multiple limitations of high-fiber ingredients simultaneously: enzymes break down anti-nutritional factors while microbials enhance nutrient utilization and mitigate negative effects, resolving the contradiction between cost-effectiveness and digestibility.

Inventive Principle:
Principle #40Composite materials

2Adaptability or versatility

If non-starch polysaccharides are present in high amounts, then alternative ingredient utilization is improved, but energy and nutrient utilization deteriorate due to indigestibility

Engineering Contradiction:
Improvealternative ingredient utilizationVSAvoidenergy utilization
Core Design Contradiction:
Adaptability or versatilityVSUse of energy by moving object

Solution Approach 1:

The enzyme components perform preliminary hydrolysis of non-starch polysaccharides before they reach the animal's digestive system. By pre-breaking down complex fibers into simpler sugars and oligosaccharides, the system makes alternative ingredients more可利用 while ensuring that the released nutrients can be efficiently utilized for energy, thus resolving the contradiction between ingredient versatility and energy utilization.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The direct-fed microbials act as intermediaries that further process the hydrolyzed products from enzymes. These microbials ferment available carbohydrates to produce short-chain fatty acids, which serve as an additional energy source for the animal. This intermediary action bridges the gap between high fiber content and effective energy utilization.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Quantity of substance

If fiber content is increased, then alternative ingredient application is improved, but nutrient intake is limited due to anti-nutritional properties

Engineering Contradiction:
Improvefiber contentVSAvoidnutrient intake
Core Design Contradiction:
Quantity of substanceVSLoss of substance

Solution Approach 1:

The patent converts the anti-nutritional properties of high fiber content into beneficial effects. The enzyme-microbial system transforms indigestible non-starch polysaccharides into digestible forms, and the microbial fermentation produces beneficial short-chain fatty acids. This converts the harmful anti-nutritional factors into useful energy sources and gut health promoters, allowing high fiber content without nutrient loss.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

4Device complexity

If xylanase alone is used for fiber degradation, then process simplicity is improved, but degradation efficiency deteriorates due to insufficient fiber breakdown

Engineering Contradiction:
Improveprocess simplicityVSAvoiddegradation efficiency
Core Design Contradiction:
Device complexityVSProductivity

Solution Approach 1:

The patent merges multiple enzymatic functions (xylanase, β-glucanase, cellulase) with microbial action into a single composition. This combination addresses the limitations of using xylanase alone by providing complementary enzyme activities that target different components of plant cell walls, achieving comprehensive fiber degradation while maintaining practical simplicity of application as a single feed additive product.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This combination significantly improves animal performance by maximizing fiber solubilization and energy extraction from plant-based ingredients, leading to enhanced digestibility, weight gain, and feed efficiency, while promoting a healthier gut microbiome.

Implementation Method 1

The present invention relates to a feed additive composition comprising a direct fed microbial, in combination with a xylanase and a β-glucanase

Methodology Applied
Scientific EffectEnzyme: Enzyme

Implementation Method 2

their capacity of producing Short Chain Fatty Acids (SCFA) from pentoses (e.g. arabinoxylans) contained in the NSP fraction of ingredients in anaerobic conditions

Methodology Applied
Scientific EffectFermentation: Fermentation

Data Source

PatentUS11931385B2Feed additive composition
Publication Date: 2024.03.19 INT N&H DENMARK APS
  • US11931385B2 patent drawing

AI summary

A feed additive composition comprising a direct fed microbial (DFM), in combination with a xylanase (e.g. endo-1,4-β-d-xylanase) and a β-glucanase (and optionally a further fibre degrading enzyme).