Feed Composition with Nucleic Acid and Lignosulfonic Acid

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Solution Overview

Problem

Current feed compositions fail to simultaneously provide immunostimulatory and mold toxin adsorbing effects while minimizing decomposition, and there is a need for an inexpensive manufacturing method.

Innovation Solution

Incorporating nucleic acid with molecular weights ranging from 5,000 to 100,000, yeast cell wall components, and ligno sulfonic acid into the feed composition, either by mixing these components separately or culturing yeast in a medium with ligno sulfonic acid and subjecting it to alkaline treatment to minimize decomposition.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If yeast extract compositions are used as feed additives, then immunostimulatory action is improved, but mold toxin adsorbing effect is not achieved

Engineering Contradiction:
Improveimmunostimulatory actionVSAvoidmold toxin adsorbing effect
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent combines yeast extract components (providing immunostimulatory action) with lignosulfonic acid (providing mold toxin adsorbing action) to create a composite feed additive that simultaneously delivers both immunostimulatory and mold toxin adsorbing effects, resolving the contradiction between single-function effectiveness and multi-function versatility

Inventive Principle:
Principle #40Composite materials

2Adaptability or versatility

If yeast cell wall extracts are used to adsorb mold toxins, then mold toxin adsorbing effect is improved, but immunostimulatory action is not achieved

Engineering Contradiction:
Improvemold toxin adsorbing effectVSAvoidimmunostimulatory action
Core Design Contradiction:
Adaptability or versatilityVSReliability

Solution Approach 1:

The patent creates a composite formulation that integrates yeast extract (for immunostimulation) with yeast cell wall extracts containing lignosulfonic acid (for mold toxin adsorption), thereby achieving both mold toxin adsorbing effect and immunostimulatory action in a single feed additive product

Inventive Principle:
Principle #40Composite materials

3Reliability

If feed is manufactured using yeast, then immunostimulatory action is provided, but decomposition occurs

Engineering Contradiction:
Improveimmunostimulatory actionVSAvoiddecomposition resistance
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent extracts and isolates stable components from yeast, specifically yeast extract and yeast cell wall extracts containing lignosulfonic acid, separating them from labile components that are prone to decomposition, thereby preserving immunostimulatory action while enhancing decomposition resistance

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent uses lignosulfonic acid, a stable and cost-effective component derived from yeast cell walls, as a reinforcing agent that provides long-term structural stability and decomposition resistance to the feed additive, compensating for the relatively short stability of yeast-derived immunostimulatory components

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

4Adaptability or versatility

If multiple efficacy components are added to feed, then both immunostimulatory and mold toxin adsorbing effects are achieved, but manufacturing cost increases

Engineering Contradiction:
Improvemultiple efficacyVSAvoidmanufacturing cost
Core Design Contradiction:
Adaptability or versatilityVSEase of manufacture

Solution Approach 1:

The patent identifies yeast extract and yeast cell wall extracts as multi-functional materials that simultaneously provide immunostimulatory action, mold toxin adsorbing effect, and decomposition resistance, eliminating the need to add multiple separate components and thereby reducing manufacturing cost while achieving multiple efficacies

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent utilizes components naturally present in yeast (yeast extract and yeast cell wall extracts containing lignosulfonic acid) that inherently possess multiple functions, allowing the feed additive to self-provide immunostimulation, mold toxin adsorption, and stability without requiring additional expensive additives or complex formulation processes

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The resulting feed composition exhibits immunostimulatory action, effective mold toxin adsorption, and resistance to decomposition, while being manufactured at a lower cost.

Implementation Method 1

inclusion of ligno sulfonic acid, which may be used as a component in a culture medium for culture of yeast, achieves provision of a feed composition that does not decompose easily

Methodology Applied
Scientific EffectProtective action of ligno sulfonic acid:

Implementation Method 2

methods of adsorbing and inactivating mycotoxins by use of yeast cell wall extracts have thus been disclosed

Methodology Applied
Scientific EffectAdsorption: Adsorption

Implementation Method 3

nucleic acid having molecular weights ranging from 5,000 to 100,000; a yeast cell wall component/yeast cell wall components; and ligno sulfonic acid

Methodology Applied
Scientific EffectImmunostimulatory action:

Data Source

PatentUS20230021363A1Feed composition and manufacturing method therefor
Publication Date: 2023.01.26 NIPPON PAPER IND CO LTD
  • US20230021363A1 patent drawing

AI summary

One of problems is to provide a feed composition having both immunostimulatory action and mold toxin adsorbing action. Another one of the problems is to provide a technique for minimizing decomposition of a feed composition made using yeast. Yet another one of the problems is to provide a method of inexpensively manufacturing the above-mentioned feed composition.The feed composition is obtained by inclusion of nucleic acid having molecular weights ranging from 5,000 to 100,000, a yeast cell wall component/yeast cell wall components, and ligno sulfonic acid. A feed composition may be manufactured by supplying nucleic acid and a yeast cell wall component that are both derived from a raw material, yeast. To supply the nucleic acid and a yeast cell wall component/yeast cell wall components from the yeast, the yeast may be subjected to alkaline treatment to prepare the nucleic acid and enucleated yeast.