Fentanyl Transdermal Patch Using Acrylic-Rubber Hybrid Adhesive
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Solution Overview
Problem
Current fentanyl transdermal patches face issues with detachment due to moisture and sweat, skin irritation, and complex production processes, leading to inconsistent drug delivery and potential health hazards from excessive absorption.
Innovation Solution
A fentanyl transdermal patch utilizing an acrylic-rubber hybrid polymer as the drug-adhesive layer, which maintains skin attachment and consistent drug delivery for three days while minimizing skin irritation and hydrophobicity, using a combination of acrylic and rubber polymers with specific monomers and additives for improved adhesion and solubility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If a reservoir type transdermal preparation with ethanol is used to accelerate skin permeation, then skin permeation is accelerated and release rate is easily controlled, but skin irritation occurs and the preparation structure becomes complicated
Solution Approach 1:
The patent changes the chemical composition parameters of the adhesive layer by using acrylic-rubber hybrid polymers with specific functional groups instead of ethanol-based reservoir systems. This parameter change maintains drug delivery speed while eliminating skin irritation caused by ethanol
Solution Approach 2:
The patent employs a composite adhesive layer made from acrylic-rubber hybrid polymers that combines the benefits of both acrylic (skin compatibility) and rubber (adhesion strength) materials, achieving effective drug delivery without the harmful effects of ethanol-based reservoir systems
2Speed
If a reservoir type transdermal preparation with multiple layers is used to control release rate, then release rate control is easy and skin permeation is accelerated, but production process becomes complicated and skin attachment is poor
Solution Approach 1:
The patent merges the drug reservoir function and adhesive function into a single integrated adhesive layer containing the acrylic-rubber hybrid polymer and fentanyl. This eliminates the need for separate reservoir, membrane, and adhesive layers, simplifying both the device structure and production process while maintaining controlled release
Solution Approach 2:
The adhesive layer serves multiple functions simultaneously: it provides skin adhesion, controls drug release rate, and enables transdermal permeation. This multi-functionality eliminates the need for separate specialized layers, reducing device complexity
3Object-affected harmful factors
If acrylic adhesives are used in matrix type monolithic patches to reduce skin irritation, then skin irritation is reduced and drug delivery is stable, but detachment occurs due to moisture and sweat
Solution Approach 1:
The patent creates a composite acrylic-rubber hybrid polymer that combines acrylic's skin compatibility (low irritation) with rubber's moisture resistance (high attachment stability). The hybrid structure allows the material to resist detachment from moisture and sweat while maintaining low skin irritation
4Loss of time
If silicone type or rubber type adhesives with fast spread rate are used to shorten lag time, then skin permeation rate is increased and lag time is shortened, but detachment occurs due to excessive hydrophobicity
Solution Approach 1:
The patent modifies the hydrophobicity parameter of the adhesive by creating an acrylic-rubber hybrid with balanced polarity. This intermediate hydrophobicity level allows fast initial spread (short lag time) while preventing excessive hydrophobicity that would cause detachment from moisture
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch achieves constant fentanyl skin permeability for three days, prevents detachment due to moisture and sweat, and reduces skin irritation, ensuring effective and safe transdermal delivery of fentanyl with improved adhesion and drug solubility.
Implementation Method 1
a fentanyl transdermal patch that includes a drug-adhesive layer comprising an acrylic-rubber hybrid to prevent detachment due to excessive moisture and sweat, thereby maintaining constant fentanyl skin permeability while maintaining close contact with the skin
Implementation Method 2
maintaining constant fentanyl skin permeability for three days
Implementation Method 3
improved adhesion and drug solubility
Data Source
AI summary
Provided is a fentanyl transdermal patch comprising an acrylic-rubber hybrid as a drug-adhesive layer. The fentanyl transdermal patch can maintain constant fentanyl skin permeability for three days by maintaining close contact with the skin such that desorption, release by moisture and sweat, and skin stimulation are all improved.