Fermented Centella Asiatica Extract for Respiratory Inflammation
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Solution Overview
Problem
Current treatments for respiratory diseases such as asthma and COPD lack effective compositions using fermented Centella asiatica extract, which has anti-inflammatory properties that could reduce inflammatory chemokine production and protect bronchial epithelial cells.
Innovation Solution
A composition comprising fermented Centella asiatica extract, produced through fermentation with lactic acid bacteria, yeast, or koji, is used to create a functional health food, pharmaceutical, animal feed additive, or veterinary product that reduces inflammatory chemokine production, protects cells, and regulates inflammatory cytokines in respiratory diseases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments for respiratory diseases are used, then current standard therapies are applied, but they lack effective compositions with sufficient anti-inflammatory properties to reduce inflammatory chemokine production and protect bronchial epithelial cells
Solution Approach 1:
The patent applies parameter changes by transforming Centella asiatica extract through fermentation processes that modify its chemical composition and enhance its anti-inflammatory properties. The fermentation process changes the parameters of the extract to increase its effectiveness in reducing inflammatory chemokine production and protecting bronchial epithelial cells, thereby improving treatment reliability for respiratory diseases.
2Reliability
If fermented Centella asiatica extract is used to reduce inflammatory chemokine production and protect bronchial epithelial cells, then anti-inflammatory effects are enhanced, but there is no prior disclosure or established composition using this specific fermented extract for respiratory disease treatment
Solution Approach 1:
The patent applies preliminary action by performing fermentation of Centella asiatica extract before its application in respiratory disease treatment. This preliminary fermentation process pre-enhances the anti-inflammatory properties of the extract, ensuring that when the composition is applied to treat respiratory diseases, it already possesses optimized effectiveness in reducing inflammatory chemokine production and protecting bronchial epithelial cells.
3Reliability
If fermentation process is applied to Centella asiatica extract, then anti-inflammatory properties are enhanced, but additional processing steps are required
Solution Approach 1:
The patent utilizes parameter changes through the fermentation process to transform Centella asiatica extract into a composition with enhanced anti-inflammatory properties. By controlling fermentation parameters such as time, temperature, and microbial culture, the extract's chemical composition is modified to increase its effectiveness in reducing inflammatory chemokine production and protecting bronchial epithelial cells, thereby improving reliability despite additional processing steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The fermented Centella asiatica extract composition significantly decreases RANTES production, protects damaged cells, reduces IL-6 expression, and lowers neutrophil counts in animal models of lung injury, demonstrating its efficacy in treating respiratory diseases.
Implementation Method 1
fermented Centella asiatica extract, produced through fermentation with lactic acid bacteria, yeast, or koji
Data Source
AI summary
A composition for preventing, ameliorating or treating a respiratory disease includes fermented Centella asiatica extract as effective component. The composition is effective in, in bronchial epithelial cells as respiratory cells, reducing the production amount of the inflammatory chemokine RANTES, protecting damaged cells induced by LPS, and reducing the expression level of the inflammatory cytokine IL-6, and it can also reduce the neutrophil count and regulate the expression level of inflammatory cytokines or chemokines in an animal model of lung injury. Accordingly, it can be advantageously used for a functional health food for preventing or ameliorating a respiratory disease, or a pharmaceutical product for preventing or treating a respiratory disease.