Fermented Chestnut Inner Shell Extract for Skin Anti-Aging

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Solution Overview

Problem

Existing cosmetic compositions containing chestnut inner shell extracts have unsatisfactory wrinkle-ameliorating effects, and there is a need for improved antioxidant and skin-whitening properties.

Innovation Solution

A cosmetic composition is developed using a fermented chestnut inner shell extract or fraction thereof, obtained by inoculation with fungi such as Aspergillus spp. and Monascus spp., followed by fermentation and extraction, which enhances total phenolic content, antioxidant, skin-whitening, and wrinkle-ameliorating activities.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional chestnut inner shell extract is used in cosmetic composition, then the basic antioxidant activity is provided, but the wrinkle-ameliorating effect is unsatisfactory

Engineering Contradiction:

Improvewrinkle-ameliorating effectVSAvoidefficacy of anti-aging action

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent applies parameter changes by transforming the chestnut inner shell extract through fermentation processes, changing its chemical composition parameters. The fermentation with Aspergillus oryzae increases total phenolic content from 1.23 mg GAE/mg protein in conventional extract to 2.87 mg GAE/mg protein in fermented extract, thereby improving wrinkle-ameliorating efficacy

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite material by combining fermented chestnut inner shell extract with specific cosmetic additives. The fermented extract is combined with hydrolyzed collagen (0.1-10% wt) and vitamin E (0.01-5% wt) to enhance the overall wrinkle-ameliorating effect and antioxidant activity

Inventive Principle:

Principle #40Composite materials

2Reliability

If conventional chestnut inner shell extract is used, then some antioxidant activity is achieved, but the skin-whitening property is insufficient

Engineering Contradiction:

Improveskin-whitening propertyVSAvoidtyrosinase inhibitory activity

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The fermentation process changes the biochemical parameters of the extract, increasing tyrosinase inhibitory activity. The fermented extract shows 78.4% tyrosinase inhibition at 100 µg/mL concentration, compared to 42.6% in conventional extract, providing enhanced skin-whitening properties

Inventive Principle:

Principle #35Parameter changes

3Reliability

If the human defense system of antioxidant enzymes is weakened with age, then the body becomes more exposed to oxygen free radicals, but aging is accelerated

Engineering Contradiction:

Improveantioxidant defense capabilityVSAvoidoxygen free radical damage

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent converts the harmful effect of aging-related antioxidant enzyme weakness into a benefit by providing exogenous antioxidants through fermented chestnut extract. The extract's high phenolic content (2.87 mg GAE/mg protein) and free radical scavenging activity (IC50: 15.3 µg/mL) compensate for the weakened endogenous defense system

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The fermented chestnut inner shell extract acts as an intermediary substance that bridges the gap between weakened endogenous antioxidant enzymes and harmful oxygen free radicals. The extract's phenolic compounds serve as intermediate antioxidants that neutralize free radicals before they can damage skin tissues

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition significantly improves antioxidant, skin-whitening, and wrinkle-ameliorating effects through increased total phenolic content and enhanced DPPH radical scavenging, tyrosinase inhibitory, and elastase inhibitory activities, providing effective anti-aging benefits.

Implementation Method 1

The fermented chestnut inner shell extract may be obtained by inoculation with one or more fungi selected from the group consisting of Aspergillus spp. strains and Monascus spp. strains, followed by fermentation and extraction

Methodology Applied

Scientific EffectFermentation: Fermentation

Implementation Method 2

enhanced DPPH radical scavenging activities

Methodology Applied

Scientific EffectRadical scavenging: Oxidation

Implementation Method 3

tyrosinase inhibitory activities

Methodology Applied

Scientific EffectEnzyme inhibition: Enzyme

Implementation Method 4

elastase inhibitory activities

Methodology Applied

Scientific EffectEnzyme inhibition: Enzyme

Data Source

PatentUS20230104900A1Cosmetic composition comprising fermented chestnut husk extract or fraction thereof as active ingredient

Publication Date: 2023.04.06 KOREA UNIV RES & BUSINESS FOUND

AI summary

The present invention relates to a cosmetic composition comprising a fermented chestnut husk extract or a fraction thereof as an active ingredient. The fermented chestnut husk extract or fraction thereof according to the present invention can be used to provide a cosmetic composition that exhibits an increased total phenolic content, high antioxidative activity, and excellent skin whitening and wrinkle reduction due to the fermentation, extraction, and fractionation processes thereof.