Fermented Panax Ginseng Composition for Hypoxia-Linked Kidney Disease
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Solution Overview
Problem
Existing treatments for kidney and vascular diseases accompanied by hypoxia are inadequate, and natural health products derived from Panax ginseng have low absorption rates due to high molecular weight, limiting their efficacy.
Innovation Solution
A Panax ginseng extract fermented with Lactobacillus plantarum strain to enhance absorption and provide hypoxia-suppressing and cholesterol-lowering effects, formulated into health functional foods or pharmaceutical compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Panax ginseng extract is used directly, then it has health benefits including antioxidant and immune-enhancing effects, but it has low absorption rate due to high molecular weight
Solution Approach 1:
The patent applies fermentation to change the molecular weight parameter of ginseng compounds. The fermentation process converts high molecular weight ginseng polysaccharides and proteins into lower molecular weight compounds that are more easily absorbed by the human body, while preserving the bioactive components responsible for health benefits
Solution Approach 2:
The patent uses Lactobacillus plantarum as an intermediary organism to facilitate the conversion of ginseng components. The bacteria act as a mediator that breaks down complex ginseng molecules into simpler, more absorbable forms through metabolic processes, enabling improved bioavailability without losing therapeutic effects
2Object-affected harmful factors
If natural raw materials are used, then they are harmless to the human body and beneficial to health, but they contain large amounts of polymer materials that do not accurately exhibit efficacy
Solution Approach 1:
The fermentation process changes the molecular size parameter of ginseng compounds, converting polymer materials into smaller molecules that can be properly absorbed and utilized by the body. This maintains the safety of natural materials while improving their efficacy by making the active components bioavailable
Solution Approach 2:
The fermentation process segments the large polymer molecules of ginseng into smaller molecular units. This segmentation allows the body to absorb and utilize the individual molecular components effectively, transforming the ineffective polymer form into bioactive monomer or oligomer forms while maintaining natural safety
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The fermented ginseng extract effectively alleviates and prevents kidney and vascular diseases by inhibiting cell death and reducing cholesterol accumulation, improving overall health outcomes.
Implementation Method 1
Fermentation is the decomposition of organic compounds by microorganisms such as yeast and bacteria, and the high molecular substance contained in natural raw materials can be converted into low molecular substance that is easy to absorb into the human body by using fermentation
Data Source
AI summary
The present invention relates to a composition for alleviating, preventing, or treating a kidney disease or a vascular disease accompanied by hypoxia, the composition comprising a Panax ginseng extract fermented with a Lactobacillus plantarum strain. When the Lactobacillus palantarum strain is treated with cells, hypoxia-suppressing and cholesterol accumulation-lowering effects are exhibited. Therefore, the composition can be effectively used in a composition for alleviating, preventing, or treating a kidney disease or a vascular disease accompanied by hypoxia.