Bacterially Fermented Hemp for CBD Bioavailability
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Solution Overview
Problem
Current CBD and CBG delivery methods often rely on extraction and isolation processes that can alter the chemical composition and lose the synergy of natural cannabinoids, leading to potential side effects and reduced efficacy, while also risking contamination from solvent residues.
Innovation Solution
Bacterially fermented native or activated hemp is used to create a powdered form containing cannabinoids, dietary fiber, vitamins, minerals, flavonoids, and amino acids, which is blended into a tablet form, retaining live bacteria and enhancing the bioavailability and efficacy of CBD/CBG through bacterial fermentation, maintaining the unextracted state of hemp and avoiding harsh solvents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If extraction and isolation processes are used to deliver CBD and CBG, then the active agents can be obtained for commercialization, but the chemical composition is altered and synergy of natural cannabinoids is lost
Solution Approach 1:
The patent applies extraction by removing unwanted components through bacterial fermentation while retaining the desired cannabinoids. The fermentation process selectively degrades certain compounds while preserving and concentrating CBD and CBG, achieving separation without harsh chemical solvents that would alter the chemical composition.
Solution Approach 2:
The patent changes the physical and chemical parameters of the hemp material through controlled bacterial fermentation. By adjusting fermentation conditions (time, temperature, bacterial strain), the composition is modified to increase desirable cannabinoids while maintaining the natural synergistic relationships among compounds.
2Quantity of substance
If extraction and isolation processes are used, then CBD and CBG can be obtained, but solvent residues may contaminate the final product
Solution Approach 1:
The patent replaces mechanical/chemical extraction systems with a biological system. Instead of using petroleum-based or alcohol-based solvents to extract cannabinoids, the invention uses bacterial fermentation—a biological process—that naturally separates and concentrates cannabinoids without leaving harmful solvent residues.
Solution Approach 2:
The patent introduces bacteria as an intermediary agent to facilitate the separation and concentration of cannabinoids. These bacterial intermediaries perform the extraction function naturally through metabolic processes, eliminating the need for direct contact with harmful chemical solvents.
3Quantity of substance
If traditional extraction methods are used, then active agents can be isolated, but beneficial co-factors are separated from the active agent
Solution Approach 1:
The patent merges the active cannabinoids (CBD, CBG) with beneficial co-factors by using whole-plant fermentation rather than isolating individual compounds. The bacterial fermentation process acts on the entire plant matrix, preserving the natural associations between cannabinoids and their synergistic co-factors like terpenes, flavonoids, and other phytochemicals.
4Quantity of substance
If bacterial fermentation is used, then desirable cannabinoids are increased by 12% to 300%, but the process complexity increases
Solution Approach 1:
The patent applies self-service by using naturally occurring or easily cultured bacteria that perform the fermentation process autonomously. The bacterial strains selected are those that naturally thrive under simple conditions and automatically carry out the cannabinoid enhancement without requiring complex process control or sophisticated equipment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method increases the presence of desirable cannabinoids by 12% to 300% and provides a balanced, whole-food effect with reduced side effects, ensuring reliable sourcing and effective delivery of CBD/CBG without solvent residues, enhancing the nutritional and dietary supplementation of hemp-based products.
Implementation Method 1
bacterially fermented native or activated unextracted hemp containing cannabinoids including but not limited to cannabidiol (CBD) and cannabigerol (CBG)... This combined increase in CBD plus CBDA, or the total of the two, is between about 12% to 300%, compared to the starting constituency of the hemp prior to fermentation
Data Source
AI summary
The present invention is a cannabidiol (CBD), cannabigerol (CBG) or related cannabinoid oral dosage form including bacterially fermented hemp, typically compounded as a tablet or formulated within a capsule or as an additive to other dietary supplements or functional foods. The dosage forms contain dietary fiber, important to activity as the desired delivery system, having a ratio of one part soluble dietary fiber to 30 parts insoluble dietary fiber, which is an optimal fiber ratio for oral delivery and bioavailability of cannabidiol, cannabigerol and other desirable cannabinoids from either activated or native hemp.