Fermented Herbal Composition for Ocular Degenerative Disease Treatment
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Solution Overview
Problem
Current treatments for age-related macular degeneration (AMD) and other diseases characterized by pathological angiogenesis, such as diabetic retinopathy and glaucoma, face challenges including partial efficacy, toxicity, and difficulty in administration, particularly for intravitreal injections, limiting patient compliance and therapeutic benefit.
Innovation Solution
A herbal composition comprising extracts of Alpinia galanga, Phyllanthus emblica, and optionally Terminalia chebula and Terminalia bellirica, fermented with Saccharomyces cerevisiae yeast, which can be formulated as a pharmaceutical or nutraceutical composition for oral administration, potentially used alone or in conjunction with anti-VEGF treatments.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current pharmacological treatments (verteporfin, anti-VEGF factors) are administered for AMD, then therapeutic effect is achieved, but toxicity and administration difficulty increase
Solution Approach 1:
The patent changes the chemical parameters of the treatment by using plant-derived compounds (curcumin, resveratrol, quercetin, catechins, flavonoids) with different molecular structures and mechanisms of action compared to conventional anti-VEGF factors. These natural compounds inhibit angiogenesis through multiple pathways while exhibiting lower toxicity profiles, thus maintaining therapeutic efficacy while reducing harmful effects.
Solution Approach 2:
The invention employs a composite formulation containing multiple plant extracts and active compounds working synergistically. This multi-component system combines anti-angiogenic, anti-inflammatory, and antioxidant properties from different plant sources, creating a composite therapeutic agent that achieves reliable treatment outcomes with reduced toxicity compared to single-agent conventional therapies.
2Reliability
If intravitreal injection is used for AMD treatment, then direct therapeutic effect is achieved, but administration difficulty and patient compliance decrease
Solution Approach 1:
The patent replaces the mechanical intrusion of intravitreal injection with an oral administration system. The active compounds are delivered through the gastrointestinal tract and absorbed systemically, eliminating the need for needle-based ocular injection. This substitution maintains therapeutic efficacy while dramatically improving ease of administration and patient compliance.
Solution Approach 2:
The herbal composition serves multiple functions simultaneously: it provides anti-angiogenic activity, anti-inflammatory effects, and antioxidant protection. This multi-functional formulation can be administered orally to treat AMD and potentially other conditions, making the treatment system more versatile and easier to implement across different clinical scenarios compared to specialized intravitreal injections.
3Object-affected harmful factors
If natural anti-oxidants and vitamin supplementation are used for AMD, then early stage benefit is achieved, but efficacy is limited to early stages
Solution Approach 1:
The invention creates a composite formulation that goes beyond simple vitamin supplementation by combining multiple plant-derived compounds with proven anti-angiogenic activities (curcumin from turmeric, resveratrol from grapes, quercetin from onions, catechins from green tea, flavonoids from citrus). This composite system addresses both early-stage oxidative stress and advanced-stage pathological angiogenesis, overcoming the局限性 of conventional vitamin-only supplements.
Solution Approach 2:
The patent changes the therapeutic parameters by using higher potency, multi-target natural compounds with demonstrated anti-angiogenic effects in advanced disease stages. These compounds act on multiple molecular pathways (VEGF inhibition, inflammatory cytokine modulation, oxidative stress reduction) simultaneously, providing effective treatment for both early and advanced AMD stages unlike conventional low-potency vitamin supplements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The herbal composition demonstrates anti-angiogenic effects, improving visual acuity and reducing symptoms in AMD patients, with a favorable safety profile and potential for enhanced bioavailability through fermentation, offering a more effective and easier-to-administer alternative to existing treatments.
Implementation Method 1
The herbal composition comprises: a first composition comprising an extract of Alpinia galanga, and a second composition comprising an extract of Phyllanthus emblica, and optionally further comprising Terminalia chebula and Terminalia bellirica extracts wherein the second, and optionally the first composition, are fermented compositions with at least one yeast, preferably a yeast of the Saccharomycetaceae family, even more preferably the yeast is Saccharomyces cerevisiae
Data Source
AI summary
The present invention relates to a herbal for use in the treatment of an ocular degenerative diseases, said composition comprising: a first composition comprising an extract of Alpinia galanga, and a second composition comprising a fermented extract of Phyllanthus emblica. The invention further relates to a process for preparing such a herbal composition.