Fermented Lactobacillus-Plant Composition for Inflammatory Bowel Disease

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Solution Overview

Problem

There is a need for alternative compositions, particularly of natural origin, with anti-inflammatory activity for the treatment and prevention of inflammatory diseases, especially inflammatory bowel disease, that are well-tolerated by patients and do not contribute to antibiotic resistance, especially for use in combination with antibiotics or in immunocompromised patients.

Innovation Solution

A fermentation product obtained by the fermentation of Lactobacillus brevis strain DSM 33682 in the presence of plant extracts such as Scutellaria baicalensis Georgi, Boswellia serrata, Phaseolus, Curcuma longa, or Camellia sinensis, or broccoli sprouts, which combines the efficacy of Lactobacillus and plant matrix metabolites.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional antibiotics are used to treat inflammatory bowel disease, then bacterial infections are eliminated, but antibiotic resistance develops and gut microbiota diversity is reduced

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidantibiotic resistance and microbiota damage

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses fermentation extracts from Lactobacillus brevis and plant materials as intermediary substances that mediate anti-inflammatory effects without directly killing bacteria. These extracts contain bioactive compounds that modulate inflammation through alternative pathways, avoiding the harmful effects of conventional antibiotics while maintaining treatment effectiveness

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention changes the therapeutic parameter from direct bacterial elimination (antibiotics) to anti-inflammatory modulation (fermentation extracts). By transforming the active ingredients into fermented metabolites and plant extract compounds, the treatment achieves anti-inflammatory effects through parameter transformation, eliminating antibiotic resistance issues

Inventive Principle:

Principle #35Parameter changes

2Reliability

If probiotics are used to modulate gut microbiota, then intestinal homeostasis is improved, but the complexity of identifying effective strains and protocols increases

Engineering Contradiction:

Improveintestinal homeostasisVSAvoidstrain selection and treatment protocol complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent employs a composite fermentation system combining Lactobacillus brevis with multiple plant extracts (curcumin, boswellia, scutellaria). This composite approach creates synergistic effects that enhance intestinal homeostasis while providing a standardized, reproducible treatment protocol that reduces the complexity of strain selection

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The invention merges probiotic fermentation with phytotherapy by combining bacterial metabolites with plant extract compounds in a single fermented product. This integration consolidates multiple therapeutic mechanisms into one treatment, simplifying the protocol while maintaining effectiveness

Inventive Principle:

Principle #5Merging (Combining)

3Reliability

If plant extracts are used alone for anti-inflammatory treatment, then natural anti-inflammatory effects are achieved, but bioavailability and absorption efficiency are limited

Engineering Contradiction:

Improveanti-inflammatory activityVSAvoidbioavailability and absorption

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The Lactobacillus brevis fermentation process serves self-function by naturally producing bioavailability-enhancing metabolites and facilitating the extraction of active compounds from plant materials. The fermentation system automatically optimizes the release and absorption of anti-inflammatory compounds without additional processing steps

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent replaces mechanical extraction methods with biological fermentation to obtain active compounds. The fermentation process naturally solubilizes and releases bioactive compounds from plant matrices, improving bioavailability through biological mechanisms rather than harsh chemical or mechanical extraction

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The fermentation product demonstrates anti-inflammatory activity comparable to mesalazine, restoring colon length, reducing inflammation markers, and improving gut microbiota diversity, effectively treating ulcerative colitis in animal models.

Implementation Method 1

a fermentation product obtained by a fermentation process of Lactobacillus brevis strain DSM 33682 in the presence of plant extracts

Methodology Applied

Scientific EffectFermentation: Fermentation

Data Source

PatentUS20250360177A1Fermentation product for the treatment of inflammatory diseases

Publication Date: 2025.11.27 ALFASIGMA SPA

AI summary

The present invention relates to a fermentation product obtained by a fermentation process of at least one bacterial strain in the presence of at least one vegetable extract. The fermentation product of a bacterial may comprise alimentary and/or pharmaceutically acceptable components or comprised in medical food or nutritional composition. The fermentation product and is useful for the treatment and/or prevention of inflammatory diseases, in particular, inflammatory bowel disease.