Fermented Milk Product GOS Stability via Enzyme Inactivation

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Solution Overview

Problem

There is a need for a method to produce post-pasteurized fermented milk products with stable levels of galacto-oligosaccharides (GOS) and low lactose levels that can be stored at ambient temperature without perish, suitable for consumption by lactose-intolerant individuals.

Innovation Solution

Inactivating the beta-galactosidase enzyme by heat treatment at a low pH, specifically between 70°C to 85°C and below pH 5, after GOS formation, to maintain stability of GOS over time and reduce lactose content in fermented milk-based products.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If beta-galactosidase enzyme is used to produce GOS in fermented milk products, then GOS levels increase providing health benefits, but the enzyme continues to degrade GOS over time reducing stability

Engineering Contradiction:
ImproveGOS levelsVSAvoidGOS stability over time
Core Design Contradiction:
Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent applies preliminary action by inactivating the beta-galactosidase enzyme through heat treatment at low pH before the product is distributed and stored. This preliminary inactivation prevents the enzyme from degrading GOS during storage, thereby maintaining GOS stability over time while preserving the GOS production benefits achieved during fermentation.

Inventive Principle:
Principle #10Preliminary action

2Stability of the object's composition

If heat treatment is applied to inactivate beta-galactosidase enzyme, then GOS stability improves, but energy consumption increases

Engineering Contradiction:
ImproveGOS stabilityVSAvoidenergy consumption
Core Design Contradiction:
Stability of the object's compositionVSUse of energy by moving object

Solution Approach 1:

The patent applies parameter changes by utilizing the low pH environment already present in fermented milk products (pH < 5 due to lactic acid fermentation) to reduce the temperature required for enzyme inactivation. Instead of requiring high temperature heat treatment, the combination of low pH and moderate heat (below 95°C) achieves enzyme inactivation, thereby reducing energy consumption while maintaining GOS stability.

Inventive Principle:
Principle #35Parameter changes

3Reliability

If high temperature heat treatment is used to inactivate enzyme, then enzyme inactivation is effective, but GOS degradation increases

Engineering Contradiction:
Improveenzyme inactivation effectivenessVSAvoidGOS degradation
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The patent applies parameter changes by exploiting the low pH condition (pH < 5) created during fermentation to enable enzyme inactivation at lower temperatures (below 95°C). This approach maintains the reliability of enzyme inactivation while avoiding the GOS degradation that would occur with high temperature treatment, thus resolving the contradiction between effective inactivation and substance preservation.

Inventive Principle:
Principle #35Parameter changes

4Ease of operation

If fermented milk products are stored at ambient temperature, then consumer convenience improves, but product shelf life and safety deteriorate

Engineering Contradiction:
Improveconsumer convenienceVSAvoidproduct shelf life and safety
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The patent applies preliminary action by inactivating the beta-galactosidase enzyme through heat treatment at low pH before distribution. This preliminary inactivation ensures that the enzyme cannot degrade GOS or cause further fermentation during ambient temperature storage, thereby extending shelf life and ensuring product safety while allowing convenient storage without refrigeration.

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method ensures the stability of GOS in fermented milk products for extended periods at room temperature, reducing lactose levels and enabling calorie reduction, while maintaining the health benefits of GOS for lactose-intolerant consumers.

Implementation Method 1

Galacto-Oligosaccharides (GOS) are non-digestable carbohydrates produced by the enzymatic treatment of lactose, by a beta-galactosidase

Methodology Applied
Scientific EffectEnzymatic hydrolysis: Hydrolysis

Implementation Method 2

The beta-galactosidase (EC 3.2.1.23) enzyme performs two different reactions, hydrolysis of lactose and transgalactosylation

Methodology Applied
Scientific EffectEnzyme catalysis: Enzyme

Implementation Method 3

The inactivation of the enzyme avoids the degradation of the GOS previously formed. Thus, this invention also relates to the method for producing the fermented milk-based product herein disclosed

Methodology Applied
Scientific EffectHeat treatment: Heat Treatment

Implementation Method 4

Inactivation of beta-galactosidases in dairy applications is done by heat treatment or, alternatively, by applying low pH

Methodology Applied
Scientific EffectEnzyme inactivation by heat: Heating

Data Source

PatentUS20240417765A1Fermented milk-based product comprising galacto-oligosaccharides and methods thereof
Publication Date: 2024.12.19 KERRY GRP SERVICES INT LTD

AI summary

The present invention relates to a fermented milk-based product comprising a combination of low levels of lactose and stable levels of galacto-oligosaccharides (GOS) produced in-situ and methods thereof.