Fermented Oyster-Seaweed Composition for Bone Health
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Solution Overview
Problem
Current treatments for osteoporosis primarily focus on suppressing bone resorption, which is insufficient for completely preventing bone loss, and there is a need for a composition that promotes bone formation to effectively prevent and treat the condition.
Innovation Solution
A functional fermented material using oysters, rich in taurine, natural GABA, and seaweed oligosaccharides, is developed by fermenting oysters and seaweed with Lactobacillus fermentum JS and/or Aspergillus usamii, which suppresses osteoclast activity and promotes osteoblast activity to enhance bone formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments focus on suppressing bone resorption, then bone loss can be partially slowed, but bone formation is not sufficiently promoted and complete prevention of bone loss cannot be achieved
Solution Approach 1:
Instead of only suppressing bone resorption (the conventional approach), the patent inverts the strategy by actively promoting bone formation through fermented oyster materials that stimulate osteoblast activity and bone matrix synthesis, thereby achieving complete prevention of bone loss by addressing both resorption and formation pathways
Solution Approach 2:
The patent changes the biochemical parameters of the treatment by using fermented oyster materials rich in taurine and other active compounds, which alter the biological environment to simultaneously reduce osteoclast activity and enhance osteoblast function, thereby improving overall treatment effectiveness
2Productivity
If fermented oyster materials are used to promote bone formation, then osteoblast activity increases, but the complexity of the composition and fermentation process increases
Solution Approach 1:
The fermentation process utilizes naturally occurring microorganisms and enzymes within the oyster material itself to break down proteins and generate active bone-forming compounds, eliminating the need for complex external processing equipment or multiple fermentation stages while still achieving high osteoblast stimulation effects
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively decreases osteoclast size and activity, increases osteoblast gene expression, and improves bone mineral density, preventing bone destruction and promoting bone formation, thus effectively addressing osteoporosis prevention and treatment.
Implementation Method 1
A functional fermented material using oysters, rich in taurine, natural GABA, and seaweed oligosaccharides, is developed by fermenting oysters and seaweed with Lactobacillus fermentum JS and/or Aspergillus usamii
Data Source
Figure 1A~1D
Figure 2
Figure 3A~3C
AI summary
The present invention relates to a composition for improving bone health, including a functional fermented material using oysters, and the composition includes a fermented extract extracted from a fermented material of oysters and seaweed, which is obtained by fermenting oysters and seaweed, and the fermented extract may promote bone formation by suppressing the activity of osteoclasts and promoting the activity of osteoblasts. According to the present invention, it is possible to provide a composition for improving bone health, containing large amounts of taurine and vitamins and containing natural gamma-aminobutyric acid (GABA) and seaweed oligosaccharides from seaweeds using oysters. Further, it is possible to provide a composition for improving bone health, including a functional fermented material using oysters which is excellent in effects of preventing and suppressing the occurrence of osteoporosis.