Fermented Papaya Preparation for Electrohypersensitivity Symptom Relief

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Solution Overview

Problem

There is no definitive scientific proof that EMF exposure causes electrohypersensitivity, but patients experience symptoms like decreased brain blood flow, cognitive impairment, and fatigue, necessitating an effective treatment.

Innovation Solution

A pharmaceutical composition containing fermented papaya preparation as an active ingredient is administered to patients, which has been shown to improve clinical symptoms by normalizing brain blood flow and reducing cognitive impairments such as short-term memory loss, impaired concentration, and fatigue.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If fermented papaya preparation is administered to treat electrohypersensitivity, then clinical symptoms improve and brain blood flow normalizes, but the mechanism of action is not fully understood due to lack of definitive scientific proof linking EMF exposure to electrohypersensitivity

Engineering Contradiction:

Improvetreatment efficacyVSAvoidmechanism understanding

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies parameter changes by administering fermented papaya preparation containing specific oligosaccharides (maltose, maltotriose) in defined concentrations to modify physiological parameters such as brain blood flow and oxidative stress markers, thereby achieving treatment of electrohypersensitivity symptoms despite incomplete mechanistic understanding

Inventive Principle:

Principle #35Parameter changes

2Ease of operation

If fermented papaya preparation is used to improve brain blood flow and reduce cognitive impairment, then patient symptoms are relieved, but the treatment requires specific fermentation conditions to produce the necessary oligosaccharide profile

Engineering Contradiction:

Improvesymptom reliefVSAvoidfermentation process control

Core Design Contradiction:

Ease of operationVSEase of manufacture

Solution Approach 1:

The patent applies preliminary action by pre-fermenting papaya extract under controlled conditions to generate the required oligosaccharide profile (maltose, maltotriose) before administration, ensuring the therapeutic composition is ready for effective symptom relief without requiring complex in-use preparation

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent applies parameter changes by controlling fermentation parameters (substrate composition, microbial culture, fermentation time and temperature) to produce specific oligosaccharide concentrations that achieve the desired therapeutic effect while maintaining manufacturing feasibility

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The treatment results in significant clinical improvement in 50 to 60% of patients, with 20 to 35% experiencing major reductions in cognitive symptoms and normalization of pulsometric indices and blood tests, indicating effective relief from electrohypersensitivity symptoms.

Implementation Method 1

A fermented papaya preparation (FPP) produced by fermenting immature fruits of Carica papaya (Carica papaya Linn) together with sugar with edible yeast

Methodology Applied

Scientific EffectFermentation: Fermentation

Data Source

PatentUS10993980B2Method for treating electrohypersensitivity with a fermented papaya preparation

Publication Date: 2021.05.04 OSATO INT

AI summary

Present disclosure provides a pharmaceutical composition or a preparation composition containing fermented papaya preparation as an active ingredient for treating a patient with electrohypersensitivity or relieving a symptom thought to be a symptom of the electrohypersensitivity, and methods of use thereof.