Composition for improving cognitive ability or memory ability, containing fermented perilla frutescens extract, and use thereof

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Solution Overview

Problem

Current treatments for cognitive and memory-related diseases, such as dementia, often come with side effects like hepatotoxicity, gastrointestinal disorders, and toxicity, necessitating the development of natural, side-effect-free alternatives that effectively improve cognitive and memory abilities.

Innovation Solution

A fermented extract of Perilla frutescens, obtained by fermenting Perilla frutescens extracts with strains like Bacillus subtilis or Lactobacillus rhamnosus, is used in compositions for improving cognitive and memory functions, potentially replacing chemical drugs by enhancing cognitive and memory abilities without adverse effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If pharmacological methods using acetylcholinesterase inhibitors are used to treat memory deterioration, then memory ability is temporarily improved, but side effects such as hepatotoxicity, gastrointestinal disorders, and toxicity occur

Engineering Contradiction:

Improvememory improvement effectivenessVSAvoidside effects (hepatotoxicity, gastrointestinal disorders, toxicity)

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters by using fermented Perilla frutescens extract instead of synthetic acetylcholinesterase inhibitors. The fermentation process transforms the extract's chemical profile, producing bioactive compounds that achieve memory improvement through natural mechanisms without the toxic side effects of pharmaceutical drugs.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs a natural plant-based extract that can be safely consumed without long-term accumulation of toxicity. The fermented extract acts as a temporary, renewable therapeutic agent that does not cause the cumulative harm associated with synthetic pharmaceuticals, allowing for sustainable long-term use.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Reliability

If surgical methods are used for memory deterioration treatment, then memory ability may be improved, but the treatment is not easy to implement

Engineering Contradiction:

Improvememory improvement effectivenessVSAvoidtreatment accessibility

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent replaces complex surgical mechanical interventions with a simple chemical/biological solution. The fermented Perilla frutescens extract provides memory improvement through biochemical mechanisms that can be administered orally or topically, eliminating the need for invasive surgical procedures and making treatment accessible to a broader population.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Reliability

If fermented extract of Perilla frutescens is used to improve cognitive and memory abilities, then cognitive and memory functions are significantly improved, but the mechanism of action needs further verification

Engineering Contradiction:

Improvecognitive and memory improvementVSAvoidmechanism verification complexity

Core Design Contradiction:

ReliabilityVSDifficulty of detecting and measuring

Solution Approach 1:

The patent employs behavioral tests (Y-maze test, spontaneous alteration tests) that provide measurable feedback on cognitive function improvement. These tests quantify memory performance and spatial learning capabilities, allowing researchers to detect and measure the effects of the fermented extract objectively, thereby verifying its mechanism of action through empirical data.

Inventive Principle:

Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The fermented extract significantly improves cognitive and memory abilities, as demonstrated by increased spontaneous alteration in mice tests, offering a natural and effective therapeutic option for cognitive and memory-related diseases.

Implementation Method 1

A fermented extract of Perilla frutescens, obtained by fermenting Perilla frutescens extracts with strains like Bacillus subtilis or Lactobacillus rhamnosus

Methodology Applied

Scientific EffectFermentation: Fermentation

Data Source

PatentUS20240293494A1Composition for improving cognitive ability or memory ability, containing fermented perilla frutescens extract, and use thereof

Publication Date: 2024.09.05 AJOU UNIV IND ACADEMIC COOP FOUND

AI summary

The present invention relates to a composition, a fiber or a fragrance composition for improving cognitive ability or memory ability, containing a fermented Perilla frutescens extract. In addition, the present invention relates to a composition for preventing, alleviating or treating cognitive ability- or memory ability-related diseases, containing a fermented Perilla frutescens extract. Furthermore, the present invention relates to a method for treating cognitive ability- or memory ability-related diseases, comprising a step of administering a fermented Perilla frutescens extract to a patient with a cognitive ability- or memory ability-related disease. Compared to an unfermented Perilla frutescens extract, a fermented Perilla frutescens extract of the present invention significantly increases cognitive ability or memory ability, thereby being effectively usable as a composition for improving cognitive ability or memory ability. Moreover, a fermented Perilla frutescens extract of the present invention can be effectively used in a composition for preventing, alleviating or treating cognitive ability- or memory ability-related diseases, or in a treatment method.