Fermented Propolis Extract for Skin Benefits

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Solution Overview

Problem

Current methods for extracting propolis do not effectively increase the artepillin C content, which is crucial for achieving skin wrinkle improvement, elasticity enhancement, whitening, antioxidation, and anti-inflammation effects.

Innovation Solution

A method involving cold extraction, ultrasonic extraction, inoculation of fermentation strains, and solvent extraction with 1,3-butylene glycol is used to increase the artepillin C content in propolis extracts, resulting in a fermented propolis extract with enhanced skin benefits.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If general extraction method is used, then extraction process is simple, but artepillin C content is low

Engineering Contradiction:
Improveartepillin C contentVSAvoidextraction process complexity
Core Design Contradiction:
Quantity of substanceVSDevice complexity

Solution Approach 1:

The extraction process is divided into multiple sequential steps: cold extraction with ethanol, ultrasonic extraction, filtration, concentration, and solvent extraction with 1,3-butylene glycol. Each step targets specific compounds and progressively concentrates the artepillin C, resolving the contradiction by achieving high content through segmented processing rather than a single complex method

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Cold extraction and ultrasonic extraction are performed as preliminary steps before the final solvent extraction. These preliminary actions prepare the propolis by releasing and concentrating target compounds, making the subsequent extraction more efficient and achieving higher artepillin C content with better process control

Inventive Principle:
Principle #10Preliminary action

2Reliability

If fermentation is applied, then skin benefits are enhanced, but process time increases

Engineering Contradiction:
Improveskin benefit effectivenessVSAvoidfermentation process time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The propolis is pre-treated through cold extraction, ultrasonic extraction, and solvent extraction before fermentation. This preliminary processing prepares the substrate optimally for fermentation, enhancing the skin benefits while controlling the fermentation time to minimize overall process duration

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The fermentation process uses controlled parameters including temperature (20-30°C), pH level (3.5-4.5), and incubation time (24-72 hours) to optimize the transformation of propolis components into skin-beneficial substances, achieving enhanced effectiveness within a controlled time frame

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method increases artepillin C content by 5.8 times, providing improved skin wrinkle, elasticity, whitening, moisturizing, antioxidation, and anti-inflammatory effects, making it suitable for cosmetic, pharmaceutical, and food compositions.

Implementation Method 1

inoculation of fermentation strains, and solvent extraction with 1,3-butylene glycol is used to increase the artepillin C content in propolis extracts

Methodology Applied
Scientific EffectFermentation: Fermentation

Implementation Method 2

cold extraction, ultrasonic extraction, inoculation of fermentation strains, and solvent extraction with 1,3-butylene glycol is used to increase the artepillin C content

Methodology Applied
Scientific EffectUltrasonic extraction: Ultrasonic Vibration

Data Source

PatentUS20240058261A1Anti-aging composition comprising fermented propolis
Publication Date: 2024.02.22 LG HOUSEHOLD & HEALTH CARE LTD
  • US20240058261A1 patent drawing
  • US20240058261A1 patent drawing
  • US20240058261A1 patent drawing

AI summary

A composition including a fermented propolis extract as an active ingredient and a method of preparing same. The composition including a fermented propolis extract as an active ingredient, according to the present invention, can be used for various applications such as improvement in skin wrinkles or skin elasticity, skin whitening, skin moisturizing, and skin antioxidant or anti-inflammatory applications. In addition, the composition can exhibit stronger effects due to the content of artepillin C that is increased by a preparation method according to the present invention.