Fermented TCM Preparation for Gout via Probiotic Bioavailability
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Solution Overview
Problem
Current treatments for gout, such as allopurinol and benzbromarone, have significant side effects and patient compliance issues due to cumbersome decoction processes, bad taste, and smell, while traditional Chinese medicine offers holistic benefits but is inconvenient and less bioavailable.
Innovation Solution
A traditional Chinese medicine fermented preparation is developed using a combination of selected probiotics like Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamnosus, and yeast to ferment a formula including Aconitum carmichaeli, Cinnamomum cassia, and other herbs, enhancing bioavailability and taste, and providing convenient dosage forms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional Chinese medicine decoction process is used, then therapeutic effects are achieved, but the process is cumbersome and inconvenient for patients
Solution Approach 1:
The patent applies preliminary action by pre-processing the Chinese herbal medicines through fermentation before patient use. The complex decoction process is replaced with a pre-fermented preparation that can be directly administered, eliminating the need for patients to perform time-consuming decoction while preserving therapeutic effects.
Solution Approach 2:
The patent introduces probiotics as an intermediary to transform the traditional Chinese medicine formula into a fermented preparation. This intermediary process converts the raw herbal materials into a bioavailable form that maintains therapeutic efficacy while improving convenience and patient compliance.
2Reliability
If traditional Chinese medicine formula is used, then holistic therapeutic benefits are achieved, but the medicine has bad smell and bad taste
Solution Approach 1:
The patent converts the harmful factors of bad smell and taste into beneficial effects through fermentation. The probiotic fermentation process transforms the unpleasant characteristics of traditional Chinese medicine into improved organoleptic properties while enhancing bioavailability and therapeutic effects.
Solution Approach 2:
The patent applies parameter changes by altering the chemical composition and physical properties of the herbal medicines through fermentation. This biochemical transformation modifies the smell, taste, and bioavailability parameters, converting traditional medicine into a more palatable and effective preparation.
3Reliability
If probiotics are used to ferment traditional Chinese medicine, then bioavailability is improved, but the preparation process becomes more complex
Solution Approach 1:
The patent merges the traditional Chinese medicine formula with probiotics in a single fermentation process. This combination approach integrates multiple functions (herbal therapy + probiotic action) into one unified preparation method, improving bioavailability without requiring separate processing steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The fermented preparation effectively prevents and treats gout by improving bioavailability, reducing oxidative stress, and enhancing patient compliance through improved absorption and intestinal microbiota regulation, with reduced side effects and increased therapeutic efficacy.
Implementation Method 1
The disclosure adopts a traditional Chinese medicine fermentation process, which combines an efficient traditional Chinese medicine formula for preventing and treating the gout with selected probiotics. Through fermentation, drug bioavailability is improved
Implementation Method 2
The fermented preparation effectively prevents and treats gout by improving bioavailability, reducing oxidative stress, and enhancing patient compliance through improved absorption
Data Source
AI summary
A traditional Chinese medicine fermented preparation for preventing and treating gout is prepared by combining a traditional Chinese medicine formula with probiotics. The traditional Chinese medicine formula includes a certain proportion of Aconitum carmichaeli, Cinnamomum cassia, Ephedra sinica, Atractylodes lancea, Saposhnikovia divaricate, Smilax glabra, Paeonia lactiflora, Anemarrhena asphodeloides, Coix lacryma-jobi, gypsum, and Glycyrrhiza uralensis. The probiotics includes Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamnosus and yeast. Drug bioavailability is improved by fermentation, maximizing therapeutic effects. A combination application of different probiotics plays a very important role in regulating and optimizing intestinal microbiota of a body, making clinical treatment of the gout more effective.