Ferromagnetic Object Clot Retraction Platelet Assessment
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Solution Overview
Problem
Current systems for assessing blood platelet function, particularly in perioperative patients, are inadequate as they often rely on non-specific clotting time measurements and do not provide comprehensive evaluation of platelet function, leading to incomplete identification of bleeding complications and increased reoperation rates.
Innovation Solution
A method and system that utilize a ferromagnetic object to assess clot retraction by measuring the distance it drops within a blood sample after clot initiation, correlating this movement with platelet function and optionally incorporating additional parameters like clot strength, to provide a more accurate evaluation of platelet function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If clotting time measurement is used to assess platelet function, then the assessment can be obtained, but the measurement is not specific to platelet function because it measures clot viscosity change
Solution Approach 1:
The patent extracts the specific platelet function assessment from the general clotting time measurement by introducing a ferromagnetic object that interacts specifically with platelets. The object's movement through the blood sample allows direct measurement of platelet-mediated clot retraction, separating this specific function from the broader clot viscosity changes measured by traditional clotting time methods.
Solution Approach 2:
The ferromagnetic object serves as an intermediary that enables specific measurement of platelet function. By tracking the movement of this object through the blood sample, the system indirectly measures platelet activity and clot retraction without being confounded by other factors affecting overall clot viscosity, thus achieving specific platelet function assessment.
2Loss of information
If existing systems evaluate all phases of the coagulation cascade, then comprehensive coagulation information is obtained, but optimal platelet function assessment is not provided
Solution Approach 1:
The patent extracts the platelet function assessment from the comprehensive coagulation cascade evaluation by using a ferromagnetic object that specifically interacts with platelets. This allows the system to isolate and measure platelet-mediated clot retraction separately from other coagulation phases, providing precise platelet function data while maintaining the ability to evaluate overall coagulation if needed.
Solution Approach 2:
The invention applies local quality by focusing the measurement on the specific aspect of platelet function (clot retraction) rather than uniformly measuring all coagulation phases. The ferromagnetic object's interaction with platelets provides localized, specific information about platelet activity, complementing the broader coagulation cascade evaluation.
3Measurement precision
If clot viscosity change is measured to indicate clot initiation, then clot initiation can be detected, but overall platelet function is not truly indicative
Solution Approach 1:
The ferromagnetic object acts as an intermediary that enables measurement of both clot initiation and overall platelet function. By tracking the object's movement through the blood sample over time, the system can detect clot initiation events while also assessing the extent and quality of platelet-mediated clot retraction, thereby obtaining comprehensive platelet function information that goes beyond simple viscosity change detection.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for a more precise assessment of platelet function, reducing the need for reoperations and improving patient outcomes by providing detailed insights into clot retraction and platelet activity, which is not achievable with existing technologies.
Implementation Method 1
allow the object to drop from the raised position and detecting a distance the object subsequently drops
Implementation Method 2
a ferromagnetic object movably disposed within the chamber. The detector configured to detect a position of the ferromagnetic object within the chamber
Data Source
AI summary
A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated. Movement of the object in the chamber is detected. The detected movement of the object is correlated with clot retraction of the blood. In some embodiments, the stop of detecting movement includes allowing the object to drop from a raised position and detecting a drop distance of the object. In related embodiments, the step of correlating detected movement with clot retraction includes reviewing a trace generated by a plurality of drop distances over time. In yet other embodiments, methods of the present disclosure can further including evaluating platelet function of the blood based upon assessed clot retraction.