Ferromagnetic Object Platelet Aggregation Analysis
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Solution Overview
Problem
Current methods for assessing platelet aggregation, such as impedance and optical measurements, require large blood samples and are not suitable for point-of-care monitoring, as they often necessitate the removal of red blood cells and are not practical for immediate patient hemostasis management and bleeding risk reduction.
Innovation Solution
A system and method utilizing a ferromagnetic object in a chamber to detect platelet aggregation by correlating its movement with platelet aggregation, where less movement indicates greater platelet aggregation, allowing for point-of-care analysis without the need for large sample volumes or removal of red blood cells.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If impedance measurement or optical measurement methods are used for platelet aggregation testing, then platelet function can be assessed, but large blood sample volume (1 mL or more) is required and red blood cells must be removed
Solution Approach 1:
The patent replaces traditional impedance or optical measurement systems with a magnetic field-based detection system. A ferromagnetic object is retained at an elevation in the chamber using a magnetic field, then released to fall through the blood sample. The movement of this object is detected and correlated with platelet aggregation, eliminating the need for large sample volumes or red blood cell removal while maintaining measurement accuracy.
2Measurement precision
If impedance measurement or optical measurement methods are used for platelet aggregation testing, then platelet function can be assessed, but the methods are not suitable for point-of-care monitoring
Solution Approach 1:
The patent replaces complex impedance or optical measurement systems with a simple magnetic field-based system that can be easily implemented at the point of care. The ferromagnetic object retention and release mechanism, combined with movement detection, provides a straightforward assay that does not require sophisticated equipment or complex sample preparation, making it suitable for point-of-care monitoring.
Solution Approach 2:
The patent changes the detection parameter from electrical impedance or optical properties to magnetic field interaction and object movement. This parameter change simplifies the measurement system and enables point-of-care implementation while maintaining the ability to accurately assess platelet function through correlation of object movement with platelet aggregation.
3Quantity of substance
If a ferromagnetic object is retained at an elevation in a chamber with blood sample, then platelet aggregation can be detected through object movement, but the system requires magnetic field application and object release mechanisms
Solution Approach 1:
The patent uses a magnetic field-based system to retain and release a ferromagnetic object in a blood sample chamber. The magnetic field application and release mechanisms, combined with movement detection, provide a straightforward assay that enables small sample volume analysis while maintaining manageable system complexity through the use of well-established magnetic field control techniques.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient and informative analysis of platelet aggregation at the point of care, providing accurate platelet function assessment without the limitations of existing methods, facilitating timely hemostasis management and bleeding risk reduction.
Implementation Method 1
The ferromagnetic object may be retained by applying a magnetic force to retain the ferromagnetic object at the elevation
Implementation Method 2
The ferromagnetic object may be released by releasing a magnetic force that retains the object
Data Source
AI summary
A method carried out by a system configured to analyze platelet aggregation includes retaining a ferromagnetic object at an elevation of a chamber in which a sample of blood or plasma is disposed. The ferromagnetic object is retained at the elevation for a period of time. The ferromagnetic object is then released from the elevation. The ferromagnetic object minimal position is measured following the release of the ferromagnetic object. The object minimal position may be correlated with amount of platelet aggregation in the sample.