Fertility Gel Composition for Sperm Activation and Vaginal Flora Support
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Solution Overview
Problem
Current fertility-enhancing products, such as vaginal lubricants and prebiotics, do not actively improve fertility or fecundation and lack ingredients like calcium and fructo-oligosaccharides (FOS) that promote sperm activation and healthy vaginal microbiota, while existing formulations may be harmful to sperm.
Innovation Solution
A gel formulation with an aqueous base, calcium, myo-inositol, and prebiotics (FOS or alpha-GOS) for postcoital use, optimizing sperm environment, promoting capacitation, and maintaining vaginal health to enhance fertility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If conventional vaginal lubricants are used to improve lubrication during intercourse, then physical lubrication is improved, but fertility enhancement is not achieved and sperm-friendly formulation is compromised
Solution Approach 1:
The patent merges the functions of vaginal lubrication and fertility enhancement into a single product formulation. The gel combines lubricating components (carboxymethylcellulose, hyaluronic acid) with fertility-promoting ingredients (calcium, myo-inositol, prebiotics FOS and alpha-GOS), allowing the product to simultaneously provide physical lubrication and actively enhance fertility through biochemical mechanisms.
Solution Approach 2:
The invention creates a multi-functional product that performs multiple tasks: it provides lubrication during intercourse, creates an optimal environment for sperm motility and capacitation, supports healthy vaginal microbiota, and promotes fecundation. This universal formulation addresses both the physical needs of intercourse and the biological needs of fertility enhancement.
2Stability of the object's composition
If products contain parabens and glycerol for preservation and physical function, then product stability and lubrication are improved, but sperm toxicity increases
Solution Approach 1:
The patent removes harmful ingredients (parabens and glycerol) from the formulation while replacing them with beneficial alternatives. The gel uses carboxymethylcellulose and hyaluronic acid as lubricating agents, and incorporates calcium, myo-inositol, and prebiotics that are beneficial for both vaginal health and sperm function, eliminating the toxic components while maintaining product stability and functionality.
Solution Approach 2:
The invention converts potentially harmful preservatives into beneficial components. Instead of using parabens and glycerol that can be toxic to sperm, the formulation uses natural prebiotics (FOS and alpha-GOS) and calcium-based compounds that not only preserve product integrity but actively promote sperm health and vaginal microbiota balance, turning the preservation function into a fertility-enhancing function.
3Reliability
If prebiotics are added to products to protect vaginal flora, then vaginal health is improved, but sperm activation and motility enhancement are not achieved
Solution Approach 1:
The patent merges prebiotic components with sperm-activating ingredients in a single gel formulation. The gel contains both prebiotics (FOS and alpha-GOS) for vaginal flora protection and calcium plus myo-inositol for sperm activation and motility enhancement, allowing simultaneous action on both vaginal health and sperm functionality through synergistic combinations.
Solution Approach 2:
The invention creates a universal formulation that performs multiple biological functions: it protects and nourishes vaginal flora through prebiotics, activates and enhances sperm motility through calcium and myo-inositol, provides lubrication, and creates an optimal environment for fecundation. This multi-functional approach ensures that both vaginal health and sperm performance are addressed simultaneously.
4Reliability
If calcium and myo-inositol are added to activate sperm and reduce non-motile spermatozoids, then sperm quality is improved, but formulation complexity increases
Solution Approach 1:
The patent optimizes the concentration parameters of active ingredients to achieve effective sperm activation without excessive formulation complexity. The gel contains calcium at 0.1-1.0%, myo-inositol at 0.01-0.5%, and prebiotics at 0.1-5.0%, these specific parameter ranges ensure biological effectiveness while maintaining manufacturability and product simplicity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The gel formulation creates an optimal environment for sperm motility and capacitation, protects sperm from vaginal conditions, and supports healthy vaginal flora, thereby enhancing short- and long-term fertility.
Implementation Method 1
a calcium component that provokes the activation in the sperm
Implementation Method 2
a prebiotic component that prevents inappropriate conditions for the sperm in the vagina
Implementation Method 3
The gel formulation creates an optimal environment for sperm motility and capacitation
Implementation Method 4
a certain amount of myoinositol that reduces the number of non-motile spermatozoids
Data Source
AI summary
A product to enhance fertility, is provided that is a gel for vaginal topic use, using a physical device (plug) in a post-coital form. The gel includes an aqueous base; a component of calcium chosen among calcium bicarbonate or calcium chloride; myo-inositol; a prebiotic, chosen among FOS or alpha-GOS; sodium phosphate, sodium hydroxide or potassium phosphate, to adjust the pH of the solution between 7 to 8.5; sodium chloride to maintain the osmolarity between 280 and 300 mOsm/l; low methylation pectin, hydroxypropylmethyl cellulose, carrageenan or polyacrylic acid to maintain the viscosity between 1.5 and 5 cP at 37° C.; hyaluronic acid; potassium sorbate; and chlorphenesin or phenoxyethanol as preserving agent.