Fertility Supplement Composition Reducing Oxidative Stress
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Solution Overview
Problem
Current fertility treatments involving hormonal or pharmacological stimulation for female infertility often come with side effects and do not adequately address oxidative stress, which affects fertility, necessitating the development of new compounds to enhance fertility while minimizing side effects.
Innovation Solution
A synergistic composition combining L-carnitine, acetyl-L-carnitine, N-acetyl cysteine, specific vitamins, amino acids, antioxidants, and microelements, such as vitamin D, vitamin E, and selenium, is used to promote female fertility during hormonal or pharmacological stimulation, reducing side effects and improving fertility outcomes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If fertility hormones or drugs are used to stimulate ovulation, then ovulation can be induced or regulated, but side effects occur and oxidative stress is not adequately addressed
Solution Approach 1:
The patent combines multiple antioxidants (vitamin C, vitamin E, selenium, zinc, copper, manganese) with specific dosages in a composite formulation. This composite approach addresses oxidative stress through synergistic interactions between different antioxidants, while the specific dosage ranges are optimized to achieve therapeutic effects without causing side effects associated with excessive antioxidant intake.
Solution Approach 2:
The patent specifies precise dosage parameters for each antioxidant component (e.g., vitamin C: 50-500 mg, vitamin E: 10-400 IU, selenium: 10-200 mcg) to optimize the therapeutic effect. By controlling these parameters within defined ranges, the formulation achieves effective oxidative stress reduction while avoiding toxicity and side effects that occur with uncontrolled or excessive dosing.
2Object-affected harmful factors
If higher doses of antioxidants are used to combat oxidative stress, then fertility may improve, but harmful effects or toxicity may occur
Solution Approach 1:
The patent defines specific dosage ranges for each antioxidant (e.g., vitamin C: 50-500 mg, vitamin E: 10-400 IU, selenium: 10-200 mcg, zinc: 1-30 mg, copper: 1-10 mg, manganese: 1-10 mg) that are sufficient to combat oxidative stress but remain below toxic thresholds. This parameter optimization ensures therapeutic effectiveness while preventing adverse effects.
Solution Approach 2:
The patent uses a balanced formulation where multiple antioxidants work together as intermediaries to moderate each other's effects. The synergistic interaction between vitamin C, vitamin E, selenium, zinc, copper, and manganese creates a buffered system that achieves oxidative stress reduction without the toxicity associated with high doses of individual antioxidants.
Data Source
AI summary
Compositions comprising L-carnitine or a salt thereof, acetyl L-carnitine or a salt thereof, vitamin B9 (folic Acid), vitamin A, vitamin B12, vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), arginine, vitamin C, vitamin E (α-Tocopherol), selenium, zinc, copper, iron, vitamin D and N-acetyl cysteine, and optionally one or more pharmaceutically acceptable excipients are provided. Dietary supplements comprising these compositions are also provided.