Fertilized Egg Isolate for Glutamate Receptor Antagonism

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Solution Overview

Problem

Current antidepressant treatments for major depressive disorder have limited efficacy and are associated with significant side effects, leading to non-compliance and relapse, necessitating the search for new compounds with novel pharmacological actions.

Innovation Solution

Fertilized egg isolates are prepared through a process involving incubation, sterilization, and freeze-drying of embryo contents, which are then used to treat mental health disorders by antagonizing glutamate and neurokinin receptors, offering a potential alternative to traditional antidepressants.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional antidepressants are used to treat major depressive disorder, then depressive symptoms are reduced, but significant side effects occur leading to non-compliance and relapse

Engineering Contradiction:

Improvetreatment efficacyVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts and isolates specific bioactive compounds from fertilized egg contents (embryo, albumen, yolk, clear sac) to create a purified isolate that can be standardized for consistent therapeutic effects. This extraction process removes unwanted substances and concentrates the active ingredients responsible for antidepressant activity, thereby reducing side effects while maintaining efficacy.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent employs freeze-drying technology to change the physical state of the egg contents, transforming them from a wet, complex matrix into a dried isolate with concentrated active compounds. This parameter change (from frozen to freeze-dried state) enhances the stability and bioavailability of the active ingredients while reducing the overall mass and potential harmful components.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If current antidepressant medications are administered, then depression symptoms improve, but patient compliance decreases due to unacceptable side effects

Engineering Contradiction:

Improvesymptom remissionVSAvoidpatient compliance

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent converts the potentially harmful complex mixture of egg contents into a beneficial purified isolate through systematic extraction and freeze-drying. By removing unwanted proteins, fats, and other substances while concentrating the active bioactive compounds, the process transforms a complex natural material into a standardized therapeutic agent with improved safety profile and patient acceptability.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Reliability

If conventional antidepressant therapy is continued for adequate duration, then relapse is prevented, but treatment duration becomes excessively long

Engineering Contradiction:

Improverelapse preventionVSAvoidtreatment duration

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent ensures continuous therapeutic action through standardized dosing of the freeze-dried isolate, which maintains stable concentrations of active compounds in the body. This continuous action helps prevent relapse more effectively than intermittent conventional medications, allowing for optimized treatment duration that balances relapse prevention with minimizing treatment time.

Inventive Principle:

Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The fertilized egg isolates demonstrate the ability to displace glutamate from its receptors and inhibit neurokinin A binding, providing a therapeutic option for depression and anxiety disorders with a different mechanism of action, potentially reducing side effects and improving treatment outcomes.

Implementation Method 1

Methodology Applied

Scientific EffectReceptor antagonism:

Implementation Method 2

Fertilized egg isolates are prepared through a process involving incubation, sterilization, and freeze-drying of embryo contents

Methodology Applied

Scientific EffectFreeze-drying: Freeze Drying

Data Source

PatentUS11285178B2Fertilized egg isolate and uses thereof

Publication Date: 2022.03.29 UNITED PARAGON ASSOCS

AI summary

Fertilized egg isolate, methods for preparing the fertilized egg isolate and uses thereof for treating mental health disorders and disease or conditions mediated by or associated with one or more glutamate receptors or by the neurokinin 2 (NK2) receptor.