Fetal Skin Cell Protein Compositions for Scarless Healing

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Solution Overview

Problem

Current therapies do not provide a mechanism for scarless healing, and existing treatments for skin conditions often rely on single active agents, which may not effectively address the complex immunologic and inflammatory pathways involved in inflammatory, neurogenic, and neuroinflammatory skin conditions.

Innovation Solution

A composition containing fetal skin cell proteins obtained from fetal skin cells through induced cell lysis, which are incorporated into a carrier for topical administration, providing a balanced orchestration of skin inflammation and regeneration, including cytokines, enzymes, and structural proteins to promote scarless healing.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If single active agents are used for treating skin conditions, then treatment simplicity is maintained, but effectiveness in addressing complex immunologic and inflammatory pathways is insufficient

Engineering Contradiction:
Improvetreatment effectivenessVSAvoidcomposition complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines multiple fetal skin cell proteins (including cytokines, growth factors, and extracellular matrix components) into a single composition that works synergistically to address complex skin conditions through coordinated immunologic and inflammatory pathway modulation

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite formulation containing multiple different fetal skin cell proteins extracted from fetal skin cells, creating a multifaceted therapeutic agent that targets multiple pathological mechanisms simultaneously

Inventive Principle:
Principle #40Composite materials

2Reliability

If fetal skin cell proteins are used to promote scarless healing, then wound repair quality is improved, but the complexity of obtaining and processing fetal skin cells increases

Engineering Contradiction:
Improvescarless healing capabilityVSAvoidprotein extraction process
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The patent collects and processes fetal skin cells during the perinatal period when they naturally exhibit scarless healing properties, extracting proteins at this optimal time before the cells lose their unique characteristics, thereby preserving their therapeutic potential

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The invention extracts specific proteins from fetal skin cells through controlled cell lysis and purification processes, isolating the active scarless-healing components while discarding unnecessary cellular material

Inventive Principle:
Principle #2Taking out (Extraction)

Data Source

PatentUS8449879B2Fetal skin cell protein compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same
Publication Date: 2013.05.28 ANTEIS SA
  • US8449879B2 patent drawing
  • US8449879B2 patent drawing
  • US8449879B2 patent drawing

AI summary

The present invention provides methods and compositions designed for treating a subject suffering from skin conditions, disorders or diseases. The compositions include fetal skin cell proteins obtained from fetal skin cells after induced cell lysis.